Services à la recherche du PRDTC pour la communauté
Depuis 2013, le PRDTC soutient la recherche et l’innovation qui s’attaquent aux obstacles dans les domaines du don et de la transplantation, dans le but de faire progresser les résultats de santé à long terme et la qualité de vie des patients transplantés canadiens. Au cours des prochaines semaines, nous mettrons en lumière les outils et les ressources que le CDTRP peut offrir pour vous aider, vous et votre projet, en vue des prochains concours de subventions du printemps.
Soutien à la communication et à l’application des connaissances
L’équipe des communications du PRDTC aide les équipes à planifier, développer et diffuser les résultats de leurs recherches. Pour la vulgarisation scientifique, nous pouvons organiser le développement, la traduction (français/anglais) et la distribution de documents FAITS EN BREF sur votre sujet de recherche pour le public et les experts. Les résultats de votre projet peuvent également être distribués par le biais de nos différentes plateformes de communication, qui comprennent les médias sociaux et les matériels et ressources éducatifs développés pour les patients, les familles et les donneurs, qui peuvent être mis en ligne sur notre portail. En 2021, 39 projets en cours ou proposés ont demandé l’aide du transfert des connaissances.
Pour de plus amples renseignements, veuillez contacter Stéphanie Larivière, Gestionnaire de données et communications du PRDTC, à l’adresse slariviere@cdtrp.ca, ou Kristian Stephens, Coordonnateur de transfert des connaissances du PRDTC, à l’adresse kstephens@cdtrp.ca.
PREMIER EXEMPLE
Soutien à l’application des connaissances pour favoriser l’impact de la recherche : Sensibiliser le public et renforcer la confiance dans le système de dons
L’étude pan-canadienne DePParT, dirigée par le Dr Sonny Dhanani de l’Institut de recherche du CHÉO, a été publiée dans le New England Journal of Medicine (28 janvier 2021), l’une des revues médicales évaluées par les pairs ayant le plus d’impact. Les familles qui choisissent le don d’organes doivent croire que la mort a vraiment eu lieu et qu’elle est permanente. Pourtant, des histoires persistent sur des personnes qui « reviennent à la vie » après une déclaration de décès, et peu de preuves ont été recueillies pour éclairer la compréhension médicale de la mort. DePParT, la plus grande étude clinique internationale sur les dons de personnes décédées au monde, n’a été rendue possible que par le cadre de collaboration du PRDTC et la participation de Mme Heather Talbot, famille de donneur partenaire et co-autrice de l’article. L’étude a montré que l’activité cardiaque s’arrête et redémarre souvent plusieurs fois au cours du processus de mort – et qu’aucun patient ne retrouve une circulation ou une conscience soutenue – et que la norme actuelle consistant à attendre cinq minutes après l’arrêt du cœur avant de déclarer le décès et de procéder au don d’organes est appropriée.
« Le PRDTC a été un soutien fondamental pour l’étude DePPaRT. De l’élaboration de la proposition au transfert des connaissances de la publication, l’organisation et ses connexions ont été la clé du succès de ce projet. »
– Dr Sonny Dhanani
En collaboration avec la responsable des communications de l’établissement principal, l’équipe des communications du PRDTC a dirigé la préparation d’un dossier de presse, organisé un point de presse pour le Dr Dhanani, la Dre West et Mme Talbot, élaboré un communiqué de presse et présenté l’histoire aux médias. En conséquence, 22 articles de presse et radios grand public ont présenté cette recherche, y compris le National Post, The Star, Reuters Health, Vice et CBC. Les efforts de sensibilisation du PRDTC dans les médias sociaux ont atteint un public de plus de 6 000 personnes en une semaine. Les familles et les équipes de soins de santé peuvent avoir confiance que lorsque le décès est déterminé, il est sécuritaire d’entamer le processus de don d’organes, et grâce au transfert de connaissance, le PRDTC a travaillé à sensibiliser le public aux preuves de recherche derrière cette pratique clinique.
DEUXIÈME EXEMPLE
PRospective Evaluation of COVID-19 Vaccine in Transplant Recipients (PREVenT-COVID): Une stratégie nationale pour faire progresser la recherche et la communication au sein de la communauté du don et de la transplantation
Le PRDTC coordonne une stratégie de recherche nationale visant à mieux comprendre les questions liées à la vaccination contre la COVID-19 chez les receveurs de greffe, notamment son efficacité et les questions relatives à la sécurité spécifique à la transplantation. Le processus a commencé par un groupe d’experts chargé d’identifier les principales lacunes en matière de connaissances. Ce groupe, qui s’est réuni le 6 janvier 2021, comprenait des experts en transplantation d’organes solides et de cellules hématopoïétiques, en maladies infectieuses liées à la transplantation, en immunisation, en santé publique ainsi des patients et familles partenaires.
Le 29 janvier 2021, le PRDTC a organisé un atelier avec des experts et des intervenants de la communauté, dans le but d’obtenir l’avis de la communauté canadienne des parties prenantes sur les sujets d’étude prioritaires et sur la façon de faire avancer les idées de recherche prioritaires vers la mise en œuvre d’une manière harmonisée et coordonnée. En plus d’établir des liens directs avec les autorités de santé publique et les décideurs concernant la recherche sur la vaccination des greffés, le PRDTC reste engagé dans un dialogue continu avec les patients, les familles et les donneurs tout au long du processus de recherche. Le 23 avril 2021, le CDTRP a organisé un deuxième atelier national, axé sur la communication de la recherche avec les patients et les familles. Kristi Coldwell (transplantée du cœur) et Nem Maksimovic (Fondation canadienne du foie) ont co-présidé l’atelier, auquel ont participé 18 patients, familles et donneurs partenaires, ainsi que des représentants d’organismes partenaires ayant un rôle d’éducation ou de communication. Ces participants représentaient un groupe diversifié de tout le Canada, comprenant des transplantés, de groupes d’âge, d’origines culturelles et de sexes différents ainsi que des proches aidants de patients pédiatriques.
ity of Alberta and has received training in patient-oriented research through the University of Calgary’s PACER (Patient and Community Engagement Research) Program. He is the Patient, Family, and Donor Partnerships & Education Manager with the Canadian Donation and Transplantation Research Program. In this role, Manuel builds relationships patient partners with investigators and strengthens capacity among CDTRP patient partners.
Anders Billström 
Gareth Wiltshire
K
Sherrie Logan 
born and raised in Edmonton, AB. With a degree in Music Performance (saxophone performance) and Education, Lindsey has taught for over a decade in the Edmonton Public School system. When she is not teaching, she is very involved in the music community, performing in the Edmonton Winds, conducting her own community ensemble (The Beer League Band) and on numerous musical boards across the province. For the past 5 years, Lindsey has had to take a break from teaching after having her amazing son, George. Maternity leave did not goes as expected as George was diagnosed with Dilated Cardiomyopathy at 5 months old and required 2 heart transplants before the age of 4. During this time, Lindsey has also began to dedicate her time building and expanding her charity: Big Gifts for Little Lives, where they raise money to fund Pediatric Heart Transplant research at the Stollery.
Dr. Caigan Du is a scientist at the Vancouver Coastal Health Research Institute and an assistant professor in the Department of Urologic Sciences at the University of British Columbia. He received a Ph.D. degree in Biochemistry in UK and postdoctoral training in Immunology in USA. He is interested in the pathogenesis of kidney ischemia-reperfusion injury and transplant rejection, and molecular control of urinary malignancies. He has been studying the impact of kidney donor-derived factors on renal allograft rejection, and the molecular pathways of kidney injury and regeneration in experimental models. He is also interested in developing medical solution including drugs made from natural compounds for all kinds of health problems, including immune disorders, organ preservation, kidney failure and urinary cancer. He is the PI of many grant supports from the Kidney Foundation of Canada and the Canadian Institutes of Health Research.
Heather Badenoch is a non-directed living liver donor and communications strategist. As the president of Village PR, she provides strategic communications direction and training to not-for-profit clients in community and health. An active transplant volunteer, Heather helps transplant candidates find living donors by running their public appeals, small and large, pro-bono. She also mentors potential living donors on the path to living donation. Heather is a volunteer with the UHN Centre for Living Organ Donation and the Canadian Donation and Transplant Research Program. She and her spouse adopt rescue dogs and volunteer together with Community Veterinary Outreach, a group providing free veterinary care to the pets of people who are homeless.
Sean Dicks is a clinical psychologist who has 20 years’ experience supporting both families of organ donors and transplant recipients. While it is rare for him to have contact with a donor family and recipient linked to the same organ donation-transplantation event, his contact with families who have lived experience with organ donation on the one hand, and patients who have received transplants on the other hand has provided opportunities to explore how their journeys become linked when they attempt to make sense of and find meaning in their respective crises.
Terri Hansen-Gardiner is a Cree speaking Metis woman from Northern Saskatchewan as well as a 10 year Breast Cancer Survivor. Her tireless spirit and dedication to her community is undeniable. Terri is a cancer survivor who travels around the province to provide assistance, information, and support to Indigenous patients who are trying to access and navigate the cancer care system.
Dr. Golnaz Karoubi is Assistant Scientist at the Toronto General HospitalResearch Institute and principal investigator in the Latner Thoracic Research Labs. She currently holds an Assistant Professor appointment in the department of Laboratory Medicine and Pathobiology and a cross-appointment in the department of Mechanical and Industrial Engineering at the University of Toronto. Dr. Karoubi received her PhD in Applied Science and Engineering at the University of Toronto and joined the Lung Regenerative Medicine Program in the Department of Clinical Research in Berne University, Switzerland for a post-doctoral research fellowship. She stayed on as a Group Leader in 2008 to direct the basic and transitional science as related to Cancer Stem Cell and Lung Regenerative Medicine in the Department of Biomedical Research at the University of Berne until 2012. In early 2012, she joined the team of Dr. Tom Waddell at the Toronto General Hospital Research Institute as a Senior Scientific Associate and was appointed to Assistant Scientist at the Toronto General Hospital Research Institute (University Health Network) in November 2019 and to Assistant Professor in the Department of Laboratory Medicine and Pathobiology in July 2020.
Dr. Haykal graduated from the University of Ottawa Faculty of Medicine in2007 as class valedictorian and silver medalist, and subsequently completed her residency training in Plastic and Reconstructive Surgery at the University of Toronto in 2016. During her residency, she completed a four-year Doctorate of Philosophy (PhD) in tissue engineering, regenerative medicine and immunology with a focus on tracheal reconstruction. She obtained numerous grants and awards including a CIHR Vanier Scholarship. Dr. Haykal then pursued fellowship training in microsurgical reconstruction at the Albany Medical Centre in New York. Dr. Haykal joined the University Health Network and the Toronto General Hospital in 2018. Her clinical focus is on complex oncological reconstruction and microsurgical reconstruction of the breast, head and neck and extremity. She started a lymphedema program in 2019 where she offers microsurgical techniques for the treatment of lymphedema.
Dr. Ahmed is a Professor in the Cumming School of Medicine at the University of Calgary. The recipient of the 2022 Hypertension Canada Senior Investigator Award, she is a nephrologist and clinician-scientist with a focus on sex and gender differences in human cardiovascular/kidney physiology and clinical outcomes. Dr. Ahmed is the Vice Chair (Research) for the Department of Medicine, Lead of the Libin Institute Women’s Cardiovascular Health Research Initiative at the University of Calgary and Lead of the Alberta Strategy for Patient Oriented Research Capacity Development Platform. Dr. Ahmed is an Advisory Board member for the Canadian Institutes of Health Research Institute of Gender and Health, a member of the Canadian Medical Association Journal Governing Council and the President-Elect for the Organization for the Study of Sex Differences.
r. Christopher Nguan is an Associate Professor at the University of British Columbia in the Department of Urological Sciences, Surgical Head of Kidney Transplantation at Vancouver General Hospital and the Director of the Surgical Technologies Experimental Laboratory & Advanced Robotics (STELLAR) facility at Vancouver General Hospital.
r Caroline Lamarche is a clinician scientist and transplant nephrologist at Maisonneuve-Rosemont Hospital. She is an assistant clinical professor at the Université de Montréal. After her nephrology training at the Université de Montréal (2015), she completed a Master degree on the use of adoptive immunotherapy to treat/prevent BK nephropathy in kidney transplant recipients. She then pursued a post-doctoral fellowship with Dr. Megan Levings at the University of British Columbia on the use of chimeric antigen receptor (CAR) regulatory T cells (Tregs) to induce transplant tolerance. Her lab is working on the development of adoptive immunotherapy in nephrology and understanding Treg dysfunction.
Dr. Tandon is an Associate Professor of Medicine, Co-Director of the Cirrhosis Care Clinic, Transplant Hepatologist and lead of the Cirrhosis Care Alberta quality improvement program. She obtained her training at the University of Alberta, the Hospital Clinic in Barcelona and Yale University. Her clinical practice and research are focused on cirrhosis with research interests including cirrhosis related complications, malnutrition, frailty, exercise therapy, palliative care, integrative health approaches such as meditation and knowledge translation. It is her career goal to provide wholistic, interdisciplinary, evidence based, patient-centered care through education, empowerment, engagement and team-work.
Emily is a PhD student at the University of Alberta, where she completed her Master of Science (MSc) degree in medicine. With a passion for patient-oriented research and a commitment to improving health outcomes, Emily’s doctoral project focuses on EMPOWER, a 12-week online mind-body wellness program designed for adults living with chronic health conditions.
Dr Basil S. Nasir, M.B.B.Ch
Dr. Victor Ferreira is an Assistant Scientist in the Ajmera Transplant Centre at the University Health Network (UHN) and the Toronto General Hospital Research Institute (TGHRI). He is also an Assistant Professor at the University of Toronto in the Department of Laboratory Medicine and Pathobiology (LMP). He completed his PhD in Medical Sciences – Infection and Immunity Specialization at McMaster University in 2014 and post-doctoral training at UHN. His research program is focused on three pillars: I) using systems vaccinology to reveal insights into vaccine responses in immunocompromised individuals like transplant recipients; II) characterizing the impact of chronic viral infection on host immune responses; and III) developing novel methods for eliminating latent viruses in human organs. His work has been cited >2,500 times and is published in journals including the New England Journal of Medicine, Nature Immunology, the Lancet Infectious Diseases, Clinical Infectious Diseases, the American Journal of Transplantation and Journal of Infectious Diseases.