Résultats du Concours 2026 de subventions pour l’innovation en recherche du PRDTC

Le PRDTC est ravi d’annoncer les résultats du Concours 2026 de subventions pour l’innovation en recherche, rendu possible grâce à des partenariats avec diverses organisations. Nous sommes fiers de présenter tous les projets innovants qui ont été financés dans le cadre du concours de cette année.

Nous tenons à féliciter chaleureusement le Dr. Michael Bleszynski et le Dr. Nicola Colucci et son équipe pour avoir reçu Organ Donation and Transplant Research Foundation of BC/CDTRP Venture Grants. Nous leur souhaitons tout le succès possible dans la réalisation de leur projet novateur!

« Research is the driving force behind progress in organ donation and transplantation. These ODTRF-funded projects showcase the innovative thinking and collaboration needed to advance the field—from improving outcomes for patients undergoing islet cell transplantation to deepening our understanding of the impact of direct contact between donor families and recipients. We are proud to support research that strengthens both the science and the human experience of organ donation and transplantation.« 

– Rachael Durie, Co-Chair, Organ Donation and Transplant Research Foundation of BC

Organ Donation and Transplant Research Foundation of BC/CDTRP Venture Grants: Dr. Michael Bleszynski et Dr. Nicola Colucci

Titre du Projet: Eliminating Static Cold Ischemia in Pancreas Preservation: A Pilot Study of Continuous Hypothermic Perfusion from Donor Procurement to Islet Isolation

Affiliation principale : University of British Columbia

Thème: 3 – Des greffons de qualité optimale

Résumé (en anglais):

When a pancreas is donated for transplantation, it must be preserved during transport from the donor hospital to the transplant center. Today, this is done by placing the organ on ice. While cooling slows down damage, it does not stop it completely. Much like food kept in a refrigerator, the organ continues to slowly deteriorate over time. For the pancreas, this is especially important because the insulin-producing cells (islets) are very sensitive and can be easily damaged. As a result, many donated pancreases yield too few healthy cells, and patients often need cells from multiple donors to become insulin-free.

This study is testing a new way to better protect the pancreas during this critical period. Instead of placing the organ on ice, we will connect it to a machine immediately after donation that gently pumps a cold, oxygen-rich fluid through it. This keeps the tissue actively supported during the journey, providing vital oxygen and nutrients instead of leaving it to slowly degrade.

We will compare this method to the current standard by studying high-quality pancreases that cannot be used for transplant due to matching issues. We will measure how well the insulin-producing cells function and how healthy they are.

Our ultimate goal is to preserve more viable cells from each donated pancreas. If successful, this approach could reduce the number of donors needed per patient and support better, longer-lasting transplant outcomes.