Recherche en vedette : L’efficacité de l’évaluation des donneurs rénaux vivants
Saviez-vous ?
- Qu’en 2019, 534 Canadiens en bonne santé ont fait don d’un rein à une personne inscrite sur la liste d’attente des greffes, dont 88 ont fait un don via le programme d’échange de reins appariés. (Source)
- Qu’au Canada, 30 % des greffes de rein sont réalisées grâce à un donneur vivant. (Source)
Au cours des dernières années, le groupe de recherche du Dr Amit Garg a produit un ensemble de travaux axés sur l’amélioration de l’efficacité de l’évaluation des donneurs, notamment la compréhension de la durée de l’évaluation et la manière de l’améliorer. Depuis 2018, les huit publications ci-dessous sont issues de ces travaux, réalisés dans le cadre d’un projet CanSOLVE-CKD.
« En ce qui concerne l’évaluation des candidats au don vivant au Canada, nous comprenons maintenant mieux : le temps que cela prend, les coûts, les solutions proposées dans la littérature, la façon dont les résultats pour les patients et les soins de santé peuvent s’améliorer avec une évaluation plus rapide, les avantages de l’évaluation simultanée de plusieurs candidats au don de rein vivant et les indicateurs qui peuvent être utilisés pour mesurer l’efficacité avec laquelle un centre de transplantation évalue les donneurs de rein vivants potentiels.
Nous devons maintenant tester des solutions pour améliorer l’efficacité et la satisfaction du processus d’évaluation des donneurs. Il s’agit notamment de stratégies telles que l’essai pilote d’une évaluation des donneurs en une journée. »
– Dre Kyla Naylor, chercheuse au CIEM et professeur auxiliaire de recherche à l’Université Western.
Liste des publications
The efficiency of evaluating candidates for living kidney donation: a scoping review
Habbous et al (2018). Transplantation (LIEN)
Cet article passe en revue la littérature sur les facteurs clés qui affectent l’efficacité de l’évaluation des donneurs vivants de rein, et identifie les lacunes dans les connaissances sur la façon dont les processus inefficaces d’évaluation des donneurs ont un impact sur les coûts des soins de santé et les résultats pour la santé des patients.
Healthcare Costs for the Evaluation, Surgery, and Follow-Up Care of Living Kidney Donors
Habbous S et al. (2018) Transplantation (LIEN).
This paper estimates the costs of living kidney donation, including donor evaluation, surgery, and follow-up in 5 Ontario transplant centers over a 10-year period.
Initiating Maintenance Dialysis Before Living Kidney Donor Transplantation When a Donor Candidate Evaluation Is Well Underway
Habbous et al. (2018), Transplantation (LIEN).
Cette étude a révélé que de nombreux patients souffrant d’insuffisance rénale commencent la dialyse même si l’évaluation de leur donneur vivant est en bonne voie, et suggère que l’amélioration de l’efficacité de l’évaluation du donneur pourrait améliorer les résultats pour le donneur et le receveur, et réduire les coûts des soins de santé.
Potential implications of a more timely living kidney donor evaluation
Habbous et al. (2018), American Journal of Transplantion (LIEN)
Ces travaux ont permis d’estimer qu’en raccourcissant de 3 mois le délai d’évaluation des donneurs vivants de rein, le système de santé de l’Ontario pourrait économiser 2,7 millions de dollars par an.
Duration of Living Kidney Transplant Donor Evaluations: Findings From 2 Multicenter Cohort Studies
Habbous et al. (2018), American Journal of Kidney Diseases (LIEN).
Cet article a déterminé le temps pris pour l’évaluation des donneurs dans plus de 20 centres de transplantation canadiens et australiens, et a associé des facteurs spécifiques aux centres qui avaient des temps d’évaluation plus longs.
Can Split Renal Volume Assessment by Computed Tomography Replace Nuclear Split Renal Function in Living Kidney Donor Evaluations? A Systematic Review and Meta-Analysis
Habbous et al. (2019), Canadian Journal of Kidney Health and Disease (LIEN).
Cette étude a examiné une stratégie potentielle pour réduire en toute sécurité le nombre de tests exigés des donneurs de rein vivants au cours de leur évaluation.
A RAND-Modified Delphi on Key Indicators to Measure the Efficiency of Living Kidney Donor Candidate Evaluations
Habbous et al. (2020), Clinical Journal of American Society of Nephrology (LIEN).
Ce travail a permis d’identifier une série d’indicateurs qui peuvent aider les centres de transplantation à mesurer efficacement l’efficacité de leur processus d’évaluation des donneurs vivants de rein.
Evaluating multiple living kidney donor candidates simultaneously is more cost-effective than sequentially
Habbous et al. (2020), Kidney International (LIEN).
Ces travaux démontrent que l’évaluation simultanée de plusieurs candidats donneurs vivants permet de réduire les coûts des soins de santé en général, car la transplantation peut se faire plus rapidement, ce qui permet d’économiser les coûts de dialyse.
Vous pouvez retrouver Amit et Kyla sur Twitter (@AmitXGarg et @kyla_naylor) et faisant partie du Thème 1 : Améliorer la culture du don, du PRDTC.
Ne manquez pas la présentation de Kyla avec Susan Mckenzie, patiente-partenaire, durant la prochaine rencontre du Thème 1, le vendredi 22 octobre à 9h00 HP | 10h00 HM | midi HE | 13h00 HA.
ity of Alberta and has received training in patient-oriented research through the University of Calgary’s PACER (Patient and Community Engagement Research) Program. He is the Patient, Family, and Donor Partnerships & Education Manager with the Canadian Donation and Transplantation Research Program. In this role, Manuel builds relationships patient partners with investigators and strengthens capacity among CDTRP patient partners.
Anders Billström 
Gareth Wiltshire
K
Sherrie Logan 
born and raised in Edmonton, AB. With a degree in Music Performance (saxophone performance) and Education, Lindsey has taught for over a decade in the Edmonton Public School system. When she is not teaching, she is very involved in the music community, performing in the Edmonton Winds, conducting her own community ensemble (The Beer League Band) and on numerous musical boards across the province. For the past 5 years, Lindsey has had to take a break from teaching after having her amazing son, George. Maternity leave did not goes as expected as George was diagnosed with Dilated Cardiomyopathy at 5 months old and required 2 heart transplants before the age of 4. During this time, Lindsey has also began to dedicate her time building and expanding her charity: Big Gifts for Little Lives, where they raise money to fund Pediatric Heart Transplant research at the Stollery.
Dr. Caigan Du is a scientist at the Vancouver Coastal Health Research Institute and an assistant professor in the Department of Urologic Sciences at the University of British Columbia. He received a Ph.D. degree in Biochemistry in UK and postdoctoral training in Immunology in USA. He is interested in the pathogenesis of kidney ischemia-reperfusion injury and transplant rejection, and molecular control of urinary malignancies. He has been studying the impact of kidney donor-derived factors on renal allograft rejection, and the molecular pathways of kidney injury and regeneration in experimental models. He is also interested in developing medical solution including drugs made from natural compounds for all kinds of health problems, including immune disorders, organ preservation, kidney failure and urinary cancer. He is the PI of many grant supports from the Kidney Foundation of Canada and the Canadian Institutes of Health Research.
Heather Badenoch is a non-directed living liver donor and communications strategist. As the president of Village PR, she provides strategic communications direction and training to not-for-profit clients in community and health. An active transplant volunteer, Heather helps transplant candidates find living donors by running their public appeals, small and large, pro-bono. She also mentors potential living donors on the path to living donation. Heather is a volunteer with the UHN Centre for Living Organ Donation and the Canadian Donation and Transplant Research Program. She and her spouse adopt rescue dogs and volunteer together with Community Veterinary Outreach, a group providing free veterinary care to the pets of people who are homeless.
Sean Dicks is a clinical psychologist who has 20 years’ experience supporting both families of organ donors and transplant recipients. While it is rare for him to have contact with a donor family and recipient linked to the same organ donation-transplantation event, his contact with families who have lived experience with organ donation on the one hand, and patients who have received transplants on the other hand has provided opportunities to explore how their journeys become linked when they attempt to make sense of and find meaning in their respective crises.
Terri Hansen-Gardiner is a Cree speaking Metis woman from Northern Saskatchewan as well as a 10 year Breast Cancer Survivor. Her tireless spirit and dedication to her community is undeniable. Terri is a cancer survivor who travels around the province to provide assistance, information, and support to Indigenous patients who are trying to access and navigate the cancer care system.
Dr. Golnaz Karoubi is Assistant Scientist at the Toronto General HospitalResearch Institute and principal investigator in the Latner Thoracic Research Labs. She currently holds an Assistant Professor appointment in the department of Laboratory Medicine and Pathobiology and a cross-appointment in the department of Mechanical and Industrial Engineering at the University of Toronto. Dr. Karoubi received her PhD in Applied Science and Engineering at the University of Toronto and joined the Lung Regenerative Medicine Program in the Department of Clinical Research in Berne University, Switzerland for a post-doctoral research fellowship. She stayed on as a Group Leader in 2008 to direct the basic and transitional science as related to Cancer Stem Cell and Lung Regenerative Medicine in the Department of Biomedical Research at the University of Berne until 2012. In early 2012, she joined the team of Dr. Tom Waddell at the Toronto General Hospital Research Institute as a Senior Scientific Associate and was appointed to Assistant Scientist at the Toronto General Hospital Research Institute (University Health Network) in November 2019 and to Assistant Professor in the Department of Laboratory Medicine and Pathobiology in July 2020.
Dr. Haykal graduated from the University of Ottawa Faculty of Medicine in2007 as class valedictorian and silver medalist, and subsequently completed her residency training in Plastic and Reconstructive Surgery at the University of Toronto in 2016. During her residency, she completed a four-year Doctorate of Philosophy (PhD) in tissue engineering, regenerative medicine and immunology with a focus on tracheal reconstruction. She obtained numerous grants and awards including a CIHR Vanier Scholarship. Dr. Haykal then pursued fellowship training in microsurgical reconstruction at the Albany Medical Centre in New York. Dr. Haykal joined the University Health Network and the Toronto General Hospital in 2018. Her clinical focus is on complex oncological reconstruction and microsurgical reconstruction of the breast, head and neck and extremity. She started a lymphedema program in 2019 where she offers microsurgical techniques for the treatment of lymphedema.
Dr. Ahmed is a Professor in the Cumming School of Medicine at the University of Calgary. The recipient of the 2022 Hypertension Canada Senior Investigator Award, she is a nephrologist and clinician-scientist with a focus on sex and gender differences in human cardiovascular/kidney physiology and clinical outcomes. Dr. Ahmed is the Vice Chair (Research) for the Department of Medicine, Lead of the Libin Institute Women’s Cardiovascular Health Research Initiative at the University of Calgary and Lead of the Alberta Strategy for Patient Oriented Research Capacity Development Platform. Dr. Ahmed is an Advisory Board member for the Canadian Institutes of Health Research Institute of Gender and Health, a member of the Canadian Medical Association Journal Governing Council and the President-Elect for the Organization for the Study of Sex Differences.
r. Christopher Nguan is an Associate Professor at the University of British Columbia in the Department of Urological Sciences, Surgical Head of Kidney Transplantation at Vancouver General Hospital and the Director of the Surgical Technologies Experimental Laboratory & Advanced Robotics (STELLAR) facility at Vancouver General Hospital.
r Caroline Lamarche is a clinician scientist and transplant nephrologist at Maisonneuve-Rosemont Hospital. She is an assistant clinical professor at the Université de Montréal. After her nephrology training at the Université de Montréal (2015), she completed a Master degree on the use of adoptive immunotherapy to treat/prevent BK nephropathy in kidney transplant recipients. She then pursued a post-doctoral fellowship with Dr. Megan Levings at the University of British Columbia on the use of chimeric antigen receptor (CAR) regulatory T cells (Tregs) to induce transplant tolerance. Her lab is working on the development of adoptive immunotherapy in nephrology and understanding Treg dysfunction.
Dr. Tandon is an Associate Professor of Medicine, Co-Director of the Cirrhosis Care Clinic, Transplant Hepatologist and lead of the Cirrhosis Care Alberta quality improvement program. She obtained her training at the University of Alberta, the Hospital Clinic in Barcelona and Yale University. Her clinical practice and research are focused on cirrhosis with research interests including cirrhosis related complications, malnutrition, frailty, exercise therapy, palliative care, integrative health approaches such as meditation and knowledge translation. It is her career goal to provide wholistic, interdisciplinary, evidence based, patient-centered care through education, empowerment, engagement and team-work.
Emily is a PhD student at the University of Alberta, where she completed her Master of Science (MSc) degree in medicine. With a passion for patient-oriented research and a commitment to improving health outcomes, Emily’s doctoral project focuses on EMPOWER, a 12-week online mind-body wellness program designed for adults living with chronic health conditions.
Dr Basil S. Nasir, M.B.B.Ch
Dr. Victor Ferreira is an Assistant Scientist in the Ajmera Transplant Centre at the University Health Network (UHN) and the Toronto General Hospital Research Institute (TGHRI). He is also an Assistant Professor at the University of Toronto in the Department of Laboratory Medicine and Pathobiology (LMP). He completed his PhD in Medical Sciences – Infection and Immunity Specialization at McMaster University in 2014 and post-doctoral training at UHN. His research program is focused on three pillars: I) using systems vaccinology to reveal insights into vaccine responses in immunocompromised individuals like transplant recipients; II) characterizing the impact of chronic viral infection on host immune responses; and III) developing novel methods for eliminating latent viruses in human organs. His work has been cited >2,500 times and is published in journals including the New England Journal of Medicine, Nature Immunology, the Lancet Infectious Diseases, Clinical Infectious Diseases, the American Journal of Transplantation and Journal of Infectious Diseases.