Le Thème 4 du PRDTC est heureux d’annoncer ses nouveaux co-responsables, les Drs Mamatha Bhat et Jonathan Choy !
Après presque dix ans, la Dre Megan Levings et le Dr Atul Humar quitteront leur rôle de responsables du thème 4, mais resteront des membres actifs du PRDTC. Nous tenons à remercier Megan et Atul pour le dévouement, la passion, l’enthousiasme et la motivation qu’ils ont apportés au Thème 4 (Un système immunitaire adapté à chaque patient) !
Dre Mamatha Bhat
La Dre Mamatha Bhat est hépatologue et clinicienne-chercheuse au programme de transplantation Ajmera du University Health Network (UHN) et professeure adjointe à la division de gastroentérologie de l’Université de Toronto. L’objectif du programme de recherche de la Dre Bhat est de permettre une approche de médecine de précision des complications à long terme après une transplantation hépatique grâce à une meilleure compréhension de leur base mécanistique. Elle étudie plus particulièrement la stéatohépatite non alcoolique, le diabète post-transplantation et le carcinome hépatocellulaire dans le contexte de la transplantation du foie. Son programme de recherche utilise un paradigme « du laboratoire au chevet du patient » qui relie les résultats cliniques à la recherche fondamentale en utilisant l’analyse bioinformatique d’ensembles de données « omiques » (par exemple, transcriptomique, miRNA, méthylation, microbiome intestinal) et des outils d’apprentissage automatique. Elle a également acquis une expérience dans l’application d’outils d’apprentissage automatique à de grands ensembles de données, validée dans des données institutionnelles. Son programme de recherche a été soutenu par des financements du PRDTC, de la NSI, de l’American Society of Transplantation et du CRSNG. Elle a reçu le prix Polanyi en 2020.
« I believe I could bring unique perspectives to developing Theme 4, as a clinician-scientist with expertise in computational biology and machine learning, as applied to patient clinical and molecular data to inform personalized care of transplant recipients. By serving as co-lead, I would like to foster learning opportunities in these areas, and help investigators incorporate such different tools into their own research and help them realize the clinical translation of their findings. »
Dr Jonathan Choy
Le Dr Jonathan Choy est professeur associé de biologie moléculaire et de biochimie à l’Université Simon Fraser. Il est immunologiste de formation et son équipe s’intéresse de près à la compréhension des mécanismes immunologiques du rejet des greffes et des lésions vasculaires associées, en utilisant la culture cellulaire, les modèles animaux et les études cliniques.
« I am excited to serve as co-lead of Theme 4 with Dr. Bhat. Since the inception of the CDTRP, Megan, Atul and Elaine have done an amazing job in developing and leading this Theme. Under their leadership, there have been many accomplishments from CDTRP researchers that contribute to understanding and potential treatment of transplant failure. They have also led the acquisition of substantial new resources to support transplant researchers across Canada. I am honored to serve in their footsteps. In the coming years, I hope to support Theme 4 researchers in their continued success in the current research landscape, with the ultimate goal of improving the lives of transplant recipients. This includes enhancing the development of collaborative teams, research opportunities with other Themes, and the visibility of Canadian transplant research. Also, increasing the engagement of trainees will be essential to ensure the future success of transplantation and donation research in Canada. Please feel free to reach out to me at any time if you have suggestions and/or questions that I can help with. »
Messages de départ
Megan et Atul ont fait partie de l’exécutif du réseau depuis la création du PNRTC en 2013. Ils resteront des membres actifs du PRDTC, mais souhaitaient s’adresser à la communauté au moment de passer le flambeau de la co-direction du Thème 4.
« It has been an incredible opportunity to part of the CDTRP since its inception almost 10 years ago. Theme 4 has achieved many milestones – from completing the CARE trial to rolling out a national immune monitoring platform to being close to ready for a first-in-human trial of thymic Tregs. I am delighted that Jonathan and Mamatha have agreed to take on the lead – with their new energy and ideas Theme 4 is well positioned to continue catalyzing transplant immunology research across the country and beyond. I look forward to connecting with all of you on future Theme 4 calls! »
– Megan Levings
« It has been my honour to serve as co-lead of theme 4. I’ve had the privilege of hearing about so many innovative projects and learning from the diverse group of people that have been part of theme 4. We are in good hands with our new leads and I look forward to continue to be part of this vibrant theme. »
– Atul Humar
ity of Alberta and has received training in patient-oriented research through the University of Calgary’s PACER (Patient and Community Engagement Research) Program. He is the Patient, Family, and Donor Partnerships & Education Manager with the Canadian Donation and Transplantation Research Program. In this role, Manuel builds relationships patient partners with investigators and strengthens capacity among CDTRP patient partners.
Anders Billström 
Gareth Wiltshire
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Sherrie Logan 
born and raised in Edmonton, AB. With a degree in Music Performance (saxophone performance) and Education, Lindsey has taught for over a decade in the Edmonton Public School system. When she is not teaching, she is very involved in the music community, performing in the Edmonton Winds, conducting her own community ensemble (The Beer League Band) and on numerous musical boards across the province. For the past 5 years, Lindsey has had to take a break from teaching after having her amazing son, George. Maternity leave did not goes as expected as George was diagnosed with Dilated Cardiomyopathy at 5 months old and required 2 heart transplants before the age of 4. During this time, Lindsey has also began to dedicate her time building and expanding her charity: Big Gifts for Little Lives, where they raise money to fund Pediatric Heart Transplant research at the Stollery.
Dr. Caigan Du is a scientist at the Vancouver Coastal Health Research Institute and an assistant professor in the Department of Urologic Sciences at the University of British Columbia. He received a Ph.D. degree in Biochemistry in UK and postdoctoral training in Immunology in USA. He is interested in the pathogenesis of kidney ischemia-reperfusion injury and transplant rejection, and molecular control of urinary malignancies. He has been studying the impact of kidney donor-derived factors on renal allograft rejection, and the molecular pathways of kidney injury and regeneration in experimental models. He is also interested in developing medical solution including drugs made from natural compounds for all kinds of health problems, including immune disorders, organ preservation, kidney failure and urinary cancer. He is the PI of many grant supports from the Kidney Foundation of Canada and the Canadian Institutes of Health Research.
Heather Badenoch is a non-directed living liver donor and communications strategist. As the president of Village PR, she provides strategic communications direction and training to not-for-profit clients in community and health. An active transplant volunteer, Heather helps transplant candidates find living donors by running their public appeals, small and large, pro-bono. She also mentors potential living donors on the path to living donation. Heather is a volunteer with the UHN Centre for Living Organ Donation and the Canadian Donation and Transplant Research Program. She and her spouse adopt rescue dogs and volunteer together with Community Veterinary Outreach, a group providing free veterinary care to the pets of people who are homeless.
Sean Dicks is a clinical psychologist who has 20 years’ experience supporting both families of organ donors and transplant recipients. While it is rare for him to have contact with a donor family and recipient linked to the same organ donation-transplantation event, his contact with families who have lived experience with organ donation on the one hand, and patients who have received transplants on the other hand has provided opportunities to explore how their journeys become linked when they attempt to make sense of and find meaning in their respective crises.
Terri Hansen-Gardiner is a Cree speaking Metis woman from Northern Saskatchewan as well as a 10 year Breast Cancer Survivor. Her tireless spirit and dedication to her community is undeniable. Terri is a cancer survivor who travels around the province to provide assistance, information, and support to Indigenous patients who are trying to access and navigate the cancer care system.
Dr. Golnaz Karoubi is Assistant Scientist at the Toronto General HospitalResearch Institute and principal investigator in the Latner Thoracic Research Labs. She currently holds an Assistant Professor appointment in the department of Laboratory Medicine and Pathobiology and a cross-appointment in the department of Mechanical and Industrial Engineering at the University of Toronto. Dr. Karoubi received her PhD in Applied Science and Engineering at the University of Toronto and joined the Lung Regenerative Medicine Program in the Department of Clinical Research in Berne University, Switzerland for a post-doctoral research fellowship. She stayed on as a Group Leader in 2008 to direct the basic and transitional science as related to Cancer Stem Cell and Lung Regenerative Medicine in the Department of Biomedical Research at the University of Berne until 2012. In early 2012, she joined the team of Dr. Tom Waddell at the Toronto General Hospital Research Institute as a Senior Scientific Associate and was appointed to Assistant Scientist at the Toronto General Hospital Research Institute (University Health Network) in November 2019 and to Assistant Professor in the Department of Laboratory Medicine and Pathobiology in July 2020.
Dr. Haykal graduated from the University of Ottawa Faculty of Medicine in2007 as class valedictorian and silver medalist, and subsequently completed her residency training in Plastic and Reconstructive Surgery at the University of Toronto in 2016. During her residency, she completed a four-year Doctorate of Philosophy (PhD) in tissue engineering, regenerative medicine and immunology with a focus on tracheal reconstruction. She obtained numerous grants and awards including a CIHR Vanier Scholarship. Dr. Haykal then pursued fellowship training in microsurgical reconstruction at the Albany Medical Centre in New York. Dr. Haykal joined the University Health Network and the Toronto General Hospital in 2018. Her clinical focus is on complex oncological reconstruction and microsurgical reconstruction of the breast, head and neck and extremity. She started a lymphedema program in 2019 where she offers microsurgical techniques for the treatment of lymphedema.
Dr. Ahmed is a Professor in the Cumming School of Medicine at the University of Calgary. The recipient of the 2022 Hypertension Canada Senior Investigator Award, she is a nephrologist and clinician-scientist with a focus on sex and gender differences in human cardiovascular/kidney physiology and clinical outcomes. Dr. Ahmed is the Vice Chair (Research) for the Department of Medicine, Lead of the Libin Institute Women’s Cardiovascular Health Research Initiative at the University of Calgary and Lead of the Alberta Strategy for Patient Oriented Research Capacity Development Platform. Dr. Ahmed is an Advisory Board member for the Canadian Institutes of Health Research Institute of Gender and Health, a member of the Canadian Medical Association Journal Governing Council and the President-Elect for the Organization for the Study of Sex Differences.
r. Christopher Nguan is an Associate Professor at the University of British Columbia in the Department of Urological Sciences, Surgical Head of Kidney Transplantation at Vancouver General Hospital and the Director of the Surgical Technologies Experimental Laboratory & Advanced Robotics (STELLAR) facility at Vancouver General Hospital.
r Caroline Lamarche is a clinician scientist and transplant nephrologist at Maisonneuve-Rosemont Hospital. She is an assistant clinical professor at the Université de Montréal. After her nephrology training at the Université de Montréal (2015), she completed a Master degree on the use of adoptive immunotherapy to treat/prevent BK nephropathy in kidney transplant recipients. She then pursued a post-doctoral fellowship with Dr. Megan Levings at the University of British Columbia on the use of chimeric antigen receptor (CAR) regulatory T cells (Tregs) to induce transplant tolerance. Her lab is working on the development of adoptive immunotherapy in nephrology and understanding Treg dysfunction.
Dr. Tandon is an Associate Professor of Medicine, Co-Director of the Cirrhosis Care Clinic, Transplant Hepatologist and lead of the Cirrhosis Care Alberta quality improvement program. She obtained her training at the University of Alberta, the Hospital Clinic in Barcelona and Yale University. Her clinical practice and research are focused on cirrhosis with research interests including cirrhosis related complications, malnutrition, frailty, exercise therapy, palliative care, integrative health approaches such as meditation and knowledge translation. It is her career goal to provide wholistic, interdisciplinary, evidence based, patient-centered care through education, empowerment, engagement and team-work.
Emily is a PhD student at the University of Alberta, where she completed her Master of Science (MSc) degree in medicine. With a passion for patient-oriented research and a commitment to improving health outcomes, Emily’s doctoral project focuses on EMPOWER, a 12-week online mind-body wellness program designed for adults living with chronic health conditions.
Dr Basil S. Nasir, M.B.B.Ch
Dr. Victor Ferreira is an Assistant Scientist in the Ajmera Transplant Centre at the University Health Network (UHN) and the Toronto General Hospital Research Institute (TGHRI). He is also an Assistant Professor at the University of Toronto in the Department of Laboratory Medicine and Pathobiology (LMP). He completed his PhD in Medical Sciences – Infection and Immunity Specialization at McMaster University in 2014 and post-doctoral training at UHN. His research program is focused on three pillars: I) using systems vaccinology to reveal insights into vaccine responses in immunocompromised individuals like transplant recipients; II) characterizing the impact of chronic viral infection on host immune responses; and III) developing novel methods for eliminating latent viruses in human organs. His work has been cited >2,500 times and is published in journals including the New England Journal of Medicine, Nature Immunology, the Lancet Infectious Diseases, Clinical Infectious Diseases, the American Journal of Transplantation and Journal of Infectious Diseases.