Résultats du Concours 2026 de subventions pour l’innovation en recherche du PRDTC

Le PRDTC est ravi d’annoncer les résultats du Concours 2026 de subventions pour l’innovation en recherche, rendu possible grâce à des partenariats avec diverses organisations. Nous sommes fiers de présenter tous les projets innovants qui ont été financés dans le cadre du concours de cette année.

Nous tenons à féliciter chaleureusement le Dr. Paraish Misra et son équipe pour avoir reçu la bourse d’innovation en recherche PRDTC KFOC. Nous leur souhaitons tout le succès possible dans la réalisation de leur projet novateur!

« The Kidney Foundation of Canada is excited to support this work which could see immunosuppression after transplantation as a thing of the past. While transplantation can provide a new outlook on life for many kidney patients, it is often accompanied by a lifelong complications resultant from the requirement to take medications to suppress the host immune system. Innovation that could contribute to the reduction of immunosuppressive medications, have the potential to result in meaningful change for the post transplant community, and increase the potential for transplant as a treatment in a larger percentage of the population. »

Bourse d’innovation en recherche PRDTC KFOC: Dr. Paraish Misra

Titre du Projet: Personalized immunomodulation after kidney transplant using donor-derived thymic epithelial cells

Affiliation principale : McGill University

Thème: 4 – Un système immunitaire adapté à chaque patient

Résumé (en anglais):

Kidney transplants give people their lives back, but powerful drugs called immunosuppressants are needed to prevent the immune system from rejecting the organ. These medications are a double-edged sword – they increase the risk of infections, cancer, and other complications and still do not work perfectly for everyone. Because of these risks, some people are considered too frail for a transplant, and for those who do get transplanted, these drugs cannot be stopped without risking rejection.

This project explores a new way to protect kidney transplants without using immunosuppressants. I will collect cells that are naturally shed into the urine of transplant recipients. These cells come from the donor kidney and carry the donor’s genetic identity. After collecting these cells, I will convert them into induced pluripotent stem cells (iPSCs), a flexible cell type that can be grown into any tissue in the body. I will then guide these iPSCs to become thymic cells. The thymus is an organ that “trains” immune cells to recognize which tissues are part of the body and which are foreign.

My long‑term goal is to use this lab-grown donor thymus to “re‑educate” the immune system so it accepts the transplanted kidney as its own. If this works, it could one day reduce the amount of immunosuppressants people need, and possibly allow some patients to stop them altogether. This would make treatment easier, improve quality of life, and may allow more people, especially those who are older or medically fragile, to safely receive kidney transplants.