CDTRP Research Connect Series

The CDTRP is pleased to host its new discussion-based meeting series called “Research Connect“.

This series streamlines the subset of Theme, Hub, and Working Group meetings that aimed to share and discuss the latest research findings across the network and our Webinar series, which featured national and international speakers. Theme, Hub, and Working Group meetings aimed at developing new initiatives, projects, or grants will be scheduled separately, approximately three times per year per group.

The new series will occur bi-monthly, on Tuesdays at 1-2 pm EST.

Our goal is to make it easy for our members to know about and attend high quality presentations across all Themes and topics of interest. We are aiming for active discussions including researchers, trainees, and patient, family, and donor partners, engaging the whole community as if we were having a family dinner rather than listening to a formal presentation.

Dr. Mingyao Liu: Molecular mechanisms and therapeutic targets of human lung transplant injury 

On February 21, we were pleased to have Dr. Mingyao Liu to present on the topic: “Molecular mechanisms and therapeutic targets of human lung transplant injury ” as part of the CDTRP Theme 3 – Engineer and Allocate Better Grafts.


Cold preservation and warm reperfusion are unavoidable steps of organ transplantation. These dramatic changes add stresses to the grafts, induce so called ischemia-reperfusion injury that led to primary graft dysfunction. To study the underlying mechanisms, animal models and clinical observations are the major tools. Over the past twenty years, we have developed a tissue bank to collect specimens from lung tissues, EVLP perfusate, patients’ plasma and bronchoalveolar lavage fluid. Recently, we used these samples to study the expression of genes (transcriptomics), proteins (proteomics), and metabolites (metabolomics). Omics is the way to study all the targeted molecules all together, in order to figure out the underlying pathways and mechanisms. These studies revealed important mechanisms that can be used as targets for develop new therapeutics.

About Dr. Mingyao Liu

Dr. Liu is a Senior Scientist and Head of the Respiratory and Critical Care Research Group at Toronto General Hospital Research Institute, UHN. Dr. Liu holds the James and Mary Davie Chair in Lung Injury, Repair and Regeneration. Dr. Liu is the Director of the Institute of Medical Science and a Professor of Surgery, Medicine and Physiology at the Temerty Faculty of Medicine, University of Toronto.

Dr. Liu has devoted his research on acute lung injury and lung transplantation. As a co-founder of the Latner Labs, Dr. Liu has teamed up with his colleague, Dr. Shaf Keshavjee, to develop ambitious lung transplantation research goals. Currently, he focuses on cellular and molecular mechanisms of ischemia-reperfusion injury in lung transplants, and developing new lung preservation solutions, EVLP perfusates and techniques.

He has received a number of research awards, including Queen Elizabeth II Diamond Jubilee Medal.