Canadian Blood Services, the Canadian Donation and Transplantation Research Program, the Canadian Society of Transplantation, and the Sir Peter Morris Centre for Evidence in Transplantation have compiled a list of ongoing clinical trials related to COVID-19 and organ donation, transplantation, immunosuppression, and others.

A team of information specialists, Robin Featherstone, Liset Pengel, and  Marc-Andre Simard, designed and executed a comprehensive search between June 18-21, 2020 with text words and controlled vocabulary terms combining concepts for COVID-19/SARS-CoV-2 and organ transplantation. Search results were limited to references published since 2019. No language or publication type limits were applied to the search.

The following clinical trials were identified during this search.  This list will be regularly updated.

Last updated: July 17, 2020

Download the search strategy here.

Updated: January 26, 2021

TrialInvestigator/InstituteURL
SARS-CoV2 Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)Antonio, Secchihttps://clinicaltrials.gov/show/NCT04487197
COVID-19 in Immunosuppressed ChildrenD'Or Institute for, Research
Education,
https://clinicaltrials.gov/show/NCT04511429
The efficacy and safety of mesenchymal stem cell transplantation in patients with COVID-19 pneumoniaHamedan University of Medical, Scienceshttp://en.irct.ir/trial/49385
SARS-COV-2 Infection in Kidney Transplant Recipients: a Brazilian Multicenter StudyHelio Tedesco Silva, Juniorhttps://clinicaltrials.gov/show/NCT04494776
Effect of COvid-19 on Mental Health in Syrian and Turkish Maintenance HemoDialysis Patients: COST-HD StudySisli Hamidiye Etfal, Training
Research, Hospital
https://clinicaltrials.gov/show/NCT04444557
Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 InfectionUniversity of California, San Diegohttps://clinicaltrials.gov/show/NCT04491227
Corona Virus Infection Among Liver Transplant RecipientsDr. Nahed A. Makhlouf, Assiut Universityhttps://clinicaltrials.gov/show/NCT04565782
Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience From the Middle EastHamid Al-Essa Organ Transplant Centerhttps://clinicaltrials.gov/show/NCT04542954
Multicenter CTS Pre-and Post-Transplantation Covid-19 Serum StudiesHeidelberg Universityhttps://clinicaltrials.gov/show/NCT04694573
Anti-Viral Effects of Voclosporin in COVID-19 Positive Kidney Transplant RecipientsLeiden University Medical Centerhttps://clinicaltrials.gov/show/NCT04701528
Evaluation of short term outcomes of liver transplantation from COVID-19 positive deceased donorsMashhad University of Medical Scienceshttp://www.who.int/trialsearch/Trial2.aspx?TrialID=IRCT20200928048867N1
Clinical and immunological predictors of SARS-CoV-2 infection and Covid-19 diseases in patients with renal diseases and healthy personsNierenzentrum Heidelberg e.V., Heidelberg Germanyhttp://www.drks.de/DRKS00021297
Prevalence and Outcome of SARS-CoV-2 Infection & COVID-19 in Transplant Recipients: The COVITRA StudyUniversitaire Ziekenhuizen, Leuvenhttps://clinicaltrials.gov/show/NCT04579471
Maintenance Versus Reduction of Immunosuppression for Renal Transplant Patients Hospitalized With COVID-19 DiseaseBrigham, Women's Hospitalhttps://clinicaltrials.gov/show/NCT04420364
Preventative treatment for patients at risk of COVID-19 infection (PROTECT)Cambridge University Hospitals, N. H. S. Foundation Trusthttp://www.isrctn.com/ISRCTN88057279
AlloSure Guided Immuno-Optimization for COVID-19: An Early ExperienceCareDxhttps://clinicaltrials.gov/show/NCT04341103
Blood Biomarkers as Predictors of COVID-19 Disease Progression in Recently Infected Kidney Transplant PatientsCentre Hospitalier Universitaire de Nicehttps://clinicaltrials.gov/show/NCT04369456
COVID-19 OUTBREAK AND SOLID ORGAN TRANSPLANTATION (SOT) : AN INTERNATIONAL WEB-BASED SURVEYFondazione Policlinico, Universitario Agostino Gemelli IRCCShttps://clinicaltrials.gov/show/NCT04367896
Multicentric Study of Coronavirus Disease 2019 (COVID-2019) in Solid Organ Transplant RecipientsFundacion Publica Andaluza para la gestion de la Investigacion en Sevillahttps://clinicaltrials.gov/ct2/show/NCT04319172
COVID-19 in Liver Transplant RecipientsHospital Clinic of Barcelonahttps://clinicaltrials.gov/show/NCT04361591
Coronavirus Outcomes Registries in Immunocompromised Individuals Australia (CORIA)Kirby Institutehttps://clinicaltrials.gov/show/NCT04354818
Humoral Immunity Against SARS-CoV-2 in Liver Transplanted Patients in Comparison With Immunocompetent PatientsMagdalena Salcedohttps://clinicaltrials.gov/show/NCT04410471
Impact of the Covid-19 Pandemic on Gastrointestinal and Liver DiseasesMedical University of Grazhttps://clinicaltrials.gov/show/NCT04420637
COVID-19 Pandemic and Worldwide Organ ProcurementParis Translational Research Center for Organ Transplantationhttps://clinicaltrials.gov/show/NCT04416256
Observational Study Concerning COVID-19 Infection in Transplanted Kidney, Pancreas or Pancreatic Islet PatientsIRCCS San Raffaelehttps://clinicaltrials.gov/show/NCT04377776
Assessment of the Impact of COVID-19 on Transplant Patients and on Patients Awaiting TransplantationUniversity Hospital, Bordeauxhttps://clinicaltrials.gov/show/NCT04376775
Solid Organ Transplant Recipients With Covid-19 French RegistryUniversity Hospital, Strasbourg Francehttps://clinicaltrials.gov/show/NCT04360707
COVID-19 Research in Organ Transplant RecipientsVastra Gotaland Regionhttps://clinicaltrials.gov/show/NCT04407221

Updated: January 26, 2021

TitleInvestigator/InstituteURL
Convalescent Plasma Treatment in COVID-19Aga Khan, Universityhttps://clinicaltrials.gov/show/NCT04476888
Is COVID-19 Transmitted Through Human Milk? Implications for Breastfeeding and Human Milk Banking-Study 1bDeborah, O'Connorhttps://clinicaltrials.gov/show/NCT04453982
Therapeutic Plasma Exchange for COVID-19-associated HyperviscosityEmory, Universityhttps://clinicaltrials.gov/show/NCT04441996
A Phase II, Open Label, Randomized Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications in Moderate DiseaseIndian Council of Medical, Researchhttp://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43149
Efficacy of Convalescent Plasma Therapy in Severely Sick COVID-19 Patients: a Pilot Randomized Controlled TrialInstitute of, Liver
Biliary, Sciences
http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43039
Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome (ARDS)Lund University, Hospitalhttps://clinicaltrials.gov/show/NCT04503057
Stem cell therapy in Covid-19Mashhad University of Medical, Scienceshttp://en.irct.ir/trial/48187
Effect of Allicin derivatives capsule in treatment of patients with new CoronavirusMashhad University of Medical, Scienceshttp://en.irct.ir/trial/48869
A Phase II, Open Label, Randomized Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated ComplicationsMax Super Speciality Hospital, A. Unit of Devki Devi Foundationhttp://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43332
COVID-19 Convalescent Plasma Treatment in SARS-CoV-2 Infected Patients: Multicenter Interventional StudyMinistry of Health, Kuwaithttps://clinicaltrials.gov/show/NCT04474340
Study to Evaluate the Safety and Efficacy of XAV-19 in Patients With COVID-19 Induced Moderate PneumoniaNantes University, Hospitalhttps://clinicaltrials.gov/show/NCT04453384
RAPA-501-Allo Off-the-Shelf Therapy of COVID-19Rapa Therapeutics, L. L. C.https://clinicaltrials.gov/show/NCT04482699
Study of investigational medicinal product CYT107 in patients with COVID-19 infection who have a low level of white blood cells in their blood (ILIAD 7 trial)Revimmune,http://isrctn.com/ISRCTN15913068
A Digital Companion for Loneliness During the COVID-19 Pandemic: a Feasibility StudyThe University of, Aucklandhttps://anzctr.org.au/ACTRN12620000786998.aspx
CovidCare 1 - Surveillance and care for confirmed and suspected patients with COVID-19 in general practice: an observational studyUniversitatsklinikum, Heidelberghttp://www.drks.de/DRKS00022054
Convalescent plasma transfusion therapy in severe COVID-19 patients- a safety, efficacy and dose response study: a structured summary of a study protocol of a phase II randomized controlled trialChowdhury Fr, Hoque A. Chowdhury F. U. H. Amin M. R. Rahim A. Rahman M. M. Yasmin R. Amin M. R. Miah M. T. Kalam M. A. Rahman M. S.https://pubmed.ncbi.nlm.nih.gov/33106167https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586693/pdf/13063_2020_Article_4734.pdf
TOGETHER 3 Trial: An Adaptive Randomized Platform Trial to Investigate the Efficacy of Novel Agents for Treatment of SARS-CoV-2 Infection Among High-Risk Outpatient Adults. COVID-19Mark Cotton, Caroline Neal, Eric Decloedthttps://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=12194
A Clinical Trial to Assess the Safety and Efficacy of Convalescent Plasma in Severe Covid-19 patientsDr Latha Bhttp://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43005
Clinical trial to evaluate superiority of anti-SARS-CoV-2 convalescent plasma versus standard-of-care in hospitalized patients with mild COVID-19Hannover Medical, Schoolhttp://www.who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2020-001936-86-DE
Use of Convalescent Plasma in the treatment of COVID-19Hilton Pharma Pvt, Ltdhttp://en.irct.ir/trial/47163
Convalescent Plasma for Severe COVID-19 PatientsHospital de Clinicas de Porto, Alegrehttps://clinicaltrials.gov/show/NCT04547660
Efficacy of Convalescent Plasma Therapy in Patients With COVID-19: a Randomized Control TrialInstitute of, Liver
Biliary, Sciences
http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44478
Evaluation of safety and efficacy of convalescent plasma in COVID-19 patientsInternational Stemcell Services, Ltdhttp://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42849
A clinical trial comparing use of convalescent plasma therapy plus standard treatment to standard treatment alone in patients with severe COVID-19 infectionKenyatta University Teaching, Referral and Research Hospitalhttps://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=11047
Study of Coagulation Profile and Role of Heparin Like Effect in Patients With COVID-19Postgraduate Institute of Medical Education and Researchhttps://clinicaltrials.gov/show/NCT04668404
The Effect of Convalescent Plasma Therapy on Patients with 19-COVIDArdabil University of Medical Scienceshttps://en.irct.ir/trial/47594
Adding Colchicine to the Antiretroviral Medication - Lopinavir/Ritonavir (Kaletra) in Hospitalized Patients with Non-Severe Covid-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomized Controlled TrialBiofarmahttps://clinicaltrials.gov/show/NCT04407208
Adding Colchicine to the Antiretroviral Medication - Lopinavir/Ritonavir (Kaletra) in Hospitalized Patients with Non-Severe Covid-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomized Controlled TrialDalili, N., Kashefizadeh, A., Nafar, M., Poorrezagholi, F., Firouzan, A., Samadian, F., Samavat, S., Ziaie, S., Fatemizadeh, Shttps://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=32503620
Evaluating the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in severely ill adults with COVID-19: a structured summary of a study protocol for a randomized controlled trialChristina M Eckhardt, Matthew J Cummings, Kartik N Rajagopalan, Sarah Borden, Zachary C Bitan, Allison Wolf, Alex Kantor, Thomas Briese, Benjamin J Meyer, Samuel D Jacobson, Dawn Scotto, Nischay Mishra, Neena M Philip, Brie A Stotler, Joseph Schwartz, Beth Shaz, Steven L Spitalnik, Andrew Eisenberger, Eldad A Hod, Jessica Justman, Ken Cheung, W Ian Lipkin, Max R O'Donnellhttps://pubmed.ncbi.nlm.nih.gov/32513308
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): a structured summary of a study protocol for a randomised, controlled trialGorman, E., Shankar-Hari, M., Hopkins, P., Tunnicliffe, W. S., Perkins, G. D., Silversides, J., McGuigan, P., Jackson, C., Boyle, R., McFerran, J., McDowell, C., Campbell, C., McFarland, M., Smythe, J., Thompson, J., Williams, B., Curley, G., Laffey, J. G., Clarke, M., O'Kane, C., McAuley, D. F.https://pubmed.ncbi.nlm.nih.gov/32493473
Convalescent Plasma of Covid-19 to Treat SARS-COV-2 a Randomized Doble Blind 2 Center TrialGrupo Mexicano para el Estudio de la Medicina Intensivahttps://clinicaltrials.gov/show/NCT04405310
Blood Donor Recruitment During Epidemic of COVID-19Guangzhou Blood Centerhttps://ClinicalTrials.gov/show/NCT04306055
Clinical Use of Stem Cells for the Treatment of Covid-19S. B. U. Dr Sadi Konuk Egitim ve Arastırma Hastanesihttps://clinicaltrials.gov/show/NCT04392778
Surgical Activity During the Covid-19 Pandemic: Results for 112 Patients in a French Tertiary Care CenterHospices Civils de Lyonhttps://clinicaltrials.gov/show/NCT04379232
Mesenchymal Stem Cell for Acute Respiratory Distress Syndrome Due for COVID-19Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiranhttps://clinicaltrials.gov/show/NCT04416139
Umbilical cord blood therapy to prevent progression of COVID-19 related pneumonia: a structured summary of a study protocol for a pilot randomised controlled trialMalhotra, Atul, Ernest, David, Rogers, Benjamin A., Haylock, David, Watt, Ashalyn, Moeneclaey, Guy, Jenkin, Grahamhttps://dx.doi.org/10.1186/s13063-020-04387-y
Study to Determine the Immunization Status Among Nephrological Health Care Personnel Against SARS-CoV-2 in a Single Center Over the Course of 12 MonthsMedical University of, Viennahttps://clinicaltrials.gov/show/NCT04347694
Clinical Study for Human Menstrual Blood-Derived Stem Cells in the Treatment of Acute Novel Coronavirus Pneumonia (COVID-19)The First Affiliated Hospital, College of Medicine, Zhejiang Universityhttp://www.chictr.org.cn/showproj.aspx?proj=49146
A Study to Collect Bone Marrow for Process Development and Production of BM-MSC to Treat Severe COVID19 PneumonitisCCTU-Cancer Themehttps://clinicaltrials.gov/show/NCT04397471
Safety of TY027, a Treatment for COVID-19, in HumansTychan Pte, Ltdhttps://clinicaltrials.gov/show/NCT04429529
Monocytes and NK Cells Activity in Covid-19 PatientsUniversita degli Studi dell'Insubriahttps://clinicaltrials.gov/show/NCT04375176
Role of Ibuprofen and Other Medicines on Severity of Coronavirus Disease 2019University Hospital, Bordeauxhttps://clinicaltrials.gov/show/NCT04383899
Safety and Efficacy of Ruxolitinib for COVID-19University of Colorado, Denverhttps://clinicaltrials.gov/show/NCT04348071