CDTRP 2025 Research Innovation Grant Competition Results

CDTRP is thrilled to announce the results of the CDTRP 2025 Research Innovation Grant Competition, made possible through our partnership with various esteemed organizations. We are proud to showcase all of the exciting projects that have been funded in this year’s competition.

We would like to extend our warmest congratulations to Dr. Manish Sadarangani and his team for being awarded the Addison Fund/CDTRP Pediatric Research Innovation Grant. We wish them all the best as they embark on their innovative project!

“For kids with organ transplants and their families, the rise in vaccine-preventable illnesses such as the ongoing measles outbreaks, is concerning. This project will provide important information so families can make informed decisions that can keep their children safe.”

– Elaine Yong, Addison Fund

Addison Fund/CDTRP Pediatric Research Innovation Grant: Dr. Manish Sadarangani

Project Title: Evaluation of vaccine uptake and associated factors influencing adherence to recommended immunization schedules among pediatric solid organ transplant recipients in BC

Main affiliation: University of British Columbia

Theme: 5 – Restore Long-Term Health

Lay Abstract

Solid organ transplant is a vital treatment for children with severe illnesses. However, the associated procedures often require lifelong treatment to suppress the immune system, in order to prevent rejection of the transplant. This leaves children who have had a transplant vulnerable to infections. Unfortunately, the multiple hospital visits can also disrupt their vaccination schedules, further increasing the risk of infection in these children who need vaccines more than anyone else. British Columbia Children’s Hospital provides care for all children in BC who have had a transplant, providing a unique opportunity for us to improve immunization rates among transplant recipients.

This project’s primary goal is to assess adherence to immunization guidelines among approximately 150 solid organ transplant recipients in BC, including kidney, liver, and heart transplant recipients. We will specifically look at whether these children are receiving vaccines as recommended, identify factors that are more common in those who have not received all the recommended vaccines, and also identify whether or not children are having blood tests to check if they have responded to their vaccines, and how doctors and nurses are using this information to decide which vaccines to give.

By pinpointing factors associated with lower vaccine uptake, the project aims to inform the adaptation of vaccination programs, develop educational materials for families, and enhance vaccine counseling in transplant clinics. Ultimately, these efforts seek to improve adherence to immunization recommendations among pediatric transplant recipients, safeguarding their health against preventable diseases.