
CDTRP 2025 Research Innovation Grant Competition Results
CDTRP is thrilled to announce the results of the CDTRP 2025 Research Innovation Grant Competition, made possible through our partnership with various esteemed organizations. We are proud to showcase all of the exciting projects that have been funded in this year’s competition.
We would like to extend our warmest congratulations to Dr. Daljeet Chahal and his team for being awarded the Organ Donation and Transplant Research Foundation of BC/CDTRP Venture Grant. We wish them all the best as they embark on their innovative project!
“We are proud to support these bold and innovative projects that address critical gaps in organ donation and transplantation research. From improving neurologic death prediction to advancing organ viability through perfusion science and elevating patient and physician voices in kidney transplantation, each project reflects our commitment to discovery, collaboration, and meaningful impact.”
Rachael Durie, ODTRF Co-Chair
Organ Donation and Transplant Research Foundation of BC/CDTRP Venture Grant: Dr. Daljeet Chahal
Project Title: Characterizing the Physiology of Hepatic Ischemia-Reperfusion Injury in Circulatory Death and Normothermic Regional Perfusion: A Feasibility Study
Main affiliation: University of British Columbia
Theme: 3 – Engineer and Allocate Better Grafts
Lay Abstract
The need for liver transplantation to treat severe liver diseases is growing in Canada, yet the number of available donor organs remains insufficient. Donor livers can come from patients who have suffered brain death, or cardiac death. Donation after cardiac death is a relatively new development. Although cardiac death donors have resulted in increased organ availability, livers from cardiac death donors are more prone to complications associated with low oxygen levels during donation. Studies suggest that a promising technique called normothermic regional perfusion (NRP) may help restore oxygen levels and improve the quality of these livers before they are transplanted. Unfortunately, we don’t fully understand how NRP affects the liver’s normal functions during this process. This research project aims to investigate the specific changes that occur in the liver during NRP. To start, we will investigate how decreased oxygen levels correlate with donor liver inflammation, how NRP impacts donor liver inflammation, and if any change in inflammation leads to an improvement in donor liver quality. By gaining a better understanding of these changes, we hope to discover ways to further enhance the quality of transplanted livers and improve the outcomes for patients. Throughout this research, we will involve patients, families, and donors to ensure that our work addresses what is most important to them.