{"id":35003,"date":"2026-10-13T21:26:09","date_gmt":"2026-10-14T01:26:09","guid":{"rendered":"https:\/\/cdtrp.ca\/bourse-dinnovation-en-recherche-prdtc-kfoc-dre-karen-sherwood-et-dr-tom-blydt-hansen\/"},"modified":"2026-10-13T21:26:10","modified_gmt":"2026-10-14T01:26:10","slug":"bourse-dinnovation-en-recherche-prdtc-kfoc-dre-karen-sherwood-et-dr-tom-blydt-hansen","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/fr\/bourse-dinnovation-en-recherche-prdtc-kfoc-dre-karen-sherwood-et-dr-tom-blydt-hansen\/","title":{"rendered":"Bourse d\u2019innovation en recherche PRDTC KFOC: Dre. Karen Sherwood et Dr. Tom Blydt-Hansen"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1600\" height=\"900\" title=\"2026 Innovation Grant1_KFOC\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant1_KFOC.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant1_KFOC.png\" alt class=\"lazyload img-responsive wp-image-34987\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant1_KFOC-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant1_KFOC-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant1_KFOC-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant1_KFOC-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant1_KFOC-1200x675.png 1200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant1_KFOC.png 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>R\u00e9sultats du Concours 2026 de subventions pour l\u2019innovation en recherche du PRDTC<\/strong><\/p>\n<p>Le PRDTC est ravi d\u2019annoncer les r\u00e9sultats du <a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/fr\/resultats-du-concours-2026-de-subventions-pour-linnovation-en-recherche-du-prdtc-7-nouveaux-projets-finances\/\">Concours 2026 de subventions pour l\u2019innovation en recherche<\/a>, rendu possible gr\u00e2ce \u00e0 des partenariats avec diverses organisations. Nous sommes fiers de pr\u00e9senter tous les projets innovants qui ont \u00e9t\u00e9 financ\u00e9s dans le cadre du concours de cette ann\u00e9e.<\/p>\n<p>Nous tenons \u00e0 f\u00e9liciter chaleureusement Dre. Karen Sherwood et Dr. Tom Blydt-Hansen et leur \u00e9quipe pour avoir re\u00e7u la <strong>bourse d\u2019innovation en recherche PRDTC KFOC<\/strong>. Nous leur souhaitons tout le succ\u00e8s possible dans la r\u00e9alisation de leur projet novateur!<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><style type='text\/css'>.reading-box-container-1 .element-bottomshadow:before,.reading-box-container-1 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-1\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em>\u00ab\u00a0The Kidney Foundation of Canada is excited to support this work which could see immunosuppression after transplantation as a thing of the past. While transplantation can provide a new outlook on life for many kidney patients, it is often accompanied by a lifelong complications resultant from the requirement to take medications to suppress the host immune system. Innovation that could contribute to the reduction of immunosuppressive medications, have the potential to result in meaningful change for the post transplant community, and increase the potential for transplant as a treatment in a larger percentage of the population.\u00a0\u00bb<\/em><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>Bourse d\u2019innovation en recherche PRDTC KFOC: Dre. Karen Sherwood et Dr. Tom Blydt-Hansen<\/strong><\/p>\n<p><strong>Titre du Projet: <\/strong>Precision Immune Genomics in Pediatric Kidney Transplantation: A Novel Application of Nanopore Adaptive Sampling for integrated genomic Risk Stratification<\/p>\n<p><strong>Affiliation principale<\/strong> : University of British Columbia<\/p>\n<p><strong>Th\u00e8me: 4 \u2013 <\/strong>Un syst\u00e8me immunitaire adapt\u00e9 \u00e0 chaque patient<\/p>\n<\/div><div class=\"fusion-text fusion-text-3\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>R\u00e9sum\u00e9 (en anglais):<\/strong><\/p>\n<\/div><style type='text\/css'>.reading-box-container-2 .element-bottomshadow:before,.reading-box-container-2 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-2\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\">Kidney transplantation gives children with kidney failure the opportunity for a longer, healthier life, but every child&rsquo;s immune system is different. Some children develop early rejection or persistent inflammation that damages their transplanted kidney, while others thrive on standard treatment. Today, we lack the tools to predict before transplant which children carry an inherently higher immune risk, leaving clinicians unable to tailor immunosuppression to the individual child.<\/p>\n<p>Answering this challenge sits at the heart of CDTRP&rsquo;s vision: to tailor an optimal immune system for each patient. This study will examine 42 variations across 28 immune-related genes in DNA samples from 200 pediatric kidney transplant recipients in British Columbia. Each gene variant has been individually linked to rejection or graft failure in other studies; however, we propose to understand how they interact in aggregate to shape each child&rsquo;s net immune response after transplantation.<\/p>\n<p>Using Oxford Nanopore adaptive sampling, a novel sequencing strategy, we will build individual genetic risk profiles and connect them to real clinical outcomes: kidney biopsies, urine inflammatory markers, and long-term graft survival. Machine learning will identify which combinations of variants best predict early rejection, allograft inflammation, and graft failure.<\/p>\n<p>The result will be a personalized pre-transplant immune risk score to guide donor selection, monitoring intensity, and immunosuppression dosing for each child. Patient, family, and donor partners are embedded throughout this work, co-developing how findings are interpreted and communicated, and ensuring that this genetic risk tool is meaningful, trustworthy, and ready for real-world clinical implementation. This precision approach directly supports the CDTRP mission of moving transplant medicine from reactive to proactive, individualized care.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h5 style=\"text-align: center;\"><strong><a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/fr\/resultats-du-concours-2026-de-subventions-pour-linnovation-en-recherche-du-prdtc-7-nouveaux-projets-finances\/\">Consultez tous les gagnants du Concours 2026 de subventions \u00e0 la recherche et l\u2019innovation du PRDTC.<\/a><\/strong><\/h5>\n<h5 style=\"text-align: center;\"><strong><a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/fr\/concours-innovation-prdtc-laureats\/\">Voyez les anciens laur\u00e9ats des subventions \u00e0 l\u2019innovation du PRDTC ici.<\/a><\/strong><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":34987,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81,37],"tags":[],"class_list":["post-35003","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-en-vedette","category-non-classifiee"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/35003","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/comments?post=35003"}],"version-history":[{"count":2,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/35003\/revisions"}],"predecessor-version":[{"id":35005,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/35003\/revisions\/35005"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media\/34987"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media?parent=35003"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/categories?post=35003"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/tags?post=35003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}