{"id":29707,"date":"2024-09-13T11:13:26","date_gmt":"2024-09-13T15:13:26","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=29707"},"modified":"2024-09-13T11:13:26","modified_gmt":"2024-09-13T15:13:26","slug":"bourse-dinnovation-en-recherche-prdtc-udem-dr-caroline-lamarche","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/fr\/bourse-dinnovation-en-recherche-prdtc-udem-dr-caroline-lamarche\/","title":{"rendered":"Bourse d&rsquo;innovation en recherche PRDTC UdeM: Dr. Caroline Lamarche"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1600\" height=\"900\" alt=\"Bourse d&amp;apos;innovation en recherche: Dr. Caroline Lamarche\" title=\"Lamarche FR\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-FR.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-FR.png\" class=\"lazyload img-responsive wp-image-29705\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-FR-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-FR-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-FR-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-FR-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-FR-1200x675.png 1200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-FR.png 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p data-pm-slice=\"1 1 &#091;&#093;\"><span style=\"color: #000000;\"><strong>R\u00e9sultats du Concours 2024 de subventions pour l\u2019innovation en recherche du PRDTC<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\">Le PRDTC est ravi d\u2019annoncer les r\u00e9sultats du<\/span> <a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/fr\/support-a-la-recherche\/concours-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Concours 2024 de subventions pour l\u2019innovation en recherche<\/a>, <span style=\"color: #000000;\">rendu possible gr\u00e2ce \u00e0 des partenariats avec diverses organisations. Nous sommes fiers de pr\u00e9senter tous les projets innovants qui ont \u00e9t\u00e9 financ\u00e9s dans le cadre du concours de cette ann\u00e9e.<\/span><\/p>\n<p><span style=\"color: #000000;\">Nous tenons \u00e0 f\u00e9liciter chaleureusement la <strong>Dre. Caroline Lamarche<\/strong> et son \u00e9quipe pour avoir re\u00e7u la <strong>bourse d&rsquo;innovation en recherche PRDTC UdeM<\/strong>. Nous leur souhaitons tout le succ\u00e8s possible dans la r\u00e9alisation de leur projet novateur !<\/span><\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><style type='text\/css'>.reading-box-container-1 .element-bottomshadow:before,.reading-box-container-1 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-1\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em>Le programme de transplantation de l&rsquo;Universit\u00e9 de Montr\u00e9al tient \u00e0 f\u00e9liciter Dre.<\/em> <em>Caroline Lamarche pour l&rsquo;obtention de la bourse d&rsquo;innovation du PRDTC lors du concours 2024 pour son projet intitul\u00e9 \u00ab\u00a0Tacrolimus-resistant regulatory T cells for adoptive immunotherapy\u00a0\u00bb. Le programme de transplantation de l&rsquo;Universit\u00e9 de Montr\u00e9al est fier de contribuer aux concours de subvention du PRDTC et ainsi participer \u00e0 la recherche en transplantation et en don d&rsquo;organes au Canada.<\/em><\/p>\n<p><em>Les 2 projets financ\u00e9s par une subvention PRDTC Universit\u00e9 de Montr\u00e9al illustrent la mission du Programme de transplantation de l&rsquo;Universit\u00e9 de Montr\u00e9al qui est de soutenir l&rsquo;innovation en recherche et en clinique afin d&rsquo;am\u00e9liorer les soins aux donneurs, familles et patients transplant\u00e9s.<\/em><\/p>\n<p><em>-Programme de transplantation de l&rsquo;Universit\u00e9 de Montr\u00e9al<\/em><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p data-pm-slice=\"1 1 &#091;&#093;\"><span style=\"color: #000000;\"><strong>Bourse d&rsquo;innovation en recherche PRDTC UdeM: Dre. Caroline Lamarche<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Titre du Projet: <\/strong>Tacrolimus-resistant regulatory T cells for adoptive immunotherapy<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Affiliation principale<\/strong>\u00a0: Universit\u00e9 de Montr\u00e9al<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Th\u00e8me: 4 &#8211; <\/strong>Un syst\u00e8me immunitaire adapt\u00e9 \u00e0 chaque patient<\/span><\/p>\n<\/div><div class=\"fusion-text fusion-text-3\"><p><span style=\"color: #000000;\"><strong>R\u00e9sum\u00e9 (en anglais):<\/strong><\/span><\/p>\n<\/div><style type='text\/css'>.reading-box-container-2 .element-bottomshadow:before,.reading-box-container-2 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-2\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\">Transplantation save lives. However, patients need to take anti-rejection drugs. Those drugs come with many side effects. For example, they increase the risk of cardiovascular diseases, infection and cancer. In the last decade, an alternative to those anti-rejection drugs has emerge. It is the injection of regulatory T cells (Tregs), the good cells of the immune system. We collect white blood cells (immune cells) from a transplant recipient. Then, we isolate the good guys (Tregs) and grow them in a laboratory. Finally, the cells are re-infused to the same patient. This was shown to be safe and doable. It allows to decrease the number of anti-rejection drugs. However, most patients still need to take tacrolimus, one of the anti-regection drug. Unfortunately, this drug also affect the good cells (Tregs) we injected. Our goal here is to modify Tregs to make them resistant to tacrolimus. Our study will have to main aims.<\/p>\n<p>First, we will study in detail the impact of tacrolimus on Tregs, the good cells. Then, we will modify the Tregs genetically, making them tacrolimus-resistant. We will show that it is possible and study the impact on the cells. The ultimate goal would be to develop this technique and bring it to a clinical trial. If Tregs are resistant to tacrolimus, it could make them more effective. Indeed, they might survive longer or grow more in patients after injection.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h5 style=\"text-align: center;\"><strong><a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/fr\/resultats-du-concours-2024-de-subventions-pour-linnovation-en-recherche-du-prdtc-8-nouveaux-projets-finances\/\">Consultez tous les gagnants du Concours 2024 de subventions \u00e0 la recherche et l\u2019innovation du PRDTC.<\/a><\/strong><\/h5>\n<h5 style=\"text-align: center;\"><strong><a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/fr\/concours-innovation-prdtc-laureats\/\">Voyez les anciens laur\u00e9ats des subventions \u00e0 l\u2019innovation du PRDTC ici.<\/a><\/strong><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":29705,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81,37],"tags":[],"class_list":["post-29707","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-en-vedette","category-non-classifiee"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/29707"}],"collection":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/comments?post=29707"}],"version-history":[{"count":3,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/29707\/revisions"}],"predecessor-version":[{"id":29710,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/29707\/revisions\/29710"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media\/29705"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media?parent=29707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/categories?post=29707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/tags?post=29707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}