{"id":29219,"date":"2024-08-06T10:32:18","date_gmt":"2024-08-06T14:32:18","guid":{"rendered":"https:\/\/cdtrp.ca\/concours-2024-de-subventions-pour-linnovation-en-recherche-du-prdtc-dr-darren-freed\/"},"modified":"2024-08-06T10:33:24","modified_gmt":"2024-08-06T14:33:24","slug":"concours-2024-de-subventions-pour-linnovation-en-recherche-du-prdtc-dr-darren-freed","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/fr\/concours-2024-de-subventions-pour-linnovation-en-recherche-du-prdtc-dr-darren-freed\/","title":{"rendered":"Concours 2024 de subventions pour l\u2019innovation en recherche du PRDTC: Dr. Darren Freed"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1600\" height=\"900\" title=\"CDTRP Innovation Grants 2024 &#8211; Freed ENG\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-ENG.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-ENG.png\" alt class=\"lazyload img-responsive wp-image-29207\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-ENG-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-ENG-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-ENG-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-ENG-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-ENG-1200x675.png 1200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-ENG.png 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>R\u00e9sultats du Concours 2024 de subventions pour l\u2019innovation en recherche du PRDTC<\/strong><\/p>\n<p>Le PRDTC est ravi d\u2019annoncer les r\u00e9sultats du <a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/fr\/support-a-la-recherche\/concours-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Concours 2024 de subventions pour l\u2019innovation en recherche<\/a>, rendu possible gr\u00e2ce \u00e0 des partenariats avec diverses organisations. Nous sommes fiers de pr\u00e9senter tous les projets innovants qui ont \u00e9t\u00e9 financ\u00e9s dans le cadre du concours de cette ann\u00e9e.<\/p>\n<p>Nous tenons \u00e0 f\u00e9liciter chaleureusement le <strong>Dr Darren Freed<\/strong> et son \u00e9quipe pour avoir re\u00e7u la <strong>bourse<\/strong> <strong>d\u2019innovation en recherche PRDTC ATI\/Paladin<\/strong>. Nous leur souhaitons tout le succ\u00e8s possible dans la r\u00e9alisation de leur projet novateur !<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><style type='text\/css'>.reading-box-container-1 .element-bottomshadow:before,.reading-box-container-1 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-1\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em>Nous f\u00e9licitons le Dr Dareen Freed, membre de l&rsquo;Alberta Transplant Institute, d&rsquo;avoir obtenu la bourse d&rsquo;innovation en recherche 2024 du PRDTC ATI\/Paladin. L&rsquo;optimisation des protocoles d&rsquo;approvisionnement en organes cardiaques est essentielle compte tenu de la raret\u00e9 des organes des donneurs. Nous attendons avec impatience les r\u00e9sultats de votre recherche sur \u00abEndothelial Glycocalyx Integrity During Heart Procurement : Impact of Crystalloid Solutions \u00bb et son impact sur l&rsquo;am\u00e9lioration des r\u00e9sultats des transplantations cardiaques.<\/em><\/p>\n<p><em>Encore une fois, nous vous f\u00e9licitons et vous souhaitons beaucoup de succ\u00e8s dans vos travaux de recherche !<\/em><\/p>\n<p><em><strong>&#8211; Alberta Transplant Institute<\/strong><\/em><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>Bourse d\u2019innovation en recherche PRDTC ATI\/Paladin : Dr.<\/strong> <strong>Darren Freed<\/strong><\/p>\n<p>Endothelial glycocalyx integrity during heart procurement: impact of crystalloid solutions<\/p>\n<p><strong>Affiliation principale<\/strong> : University of Alberta<\/p>\n<p><strong>Th\u00e8me: 3<\/strong> &#8211; Des greffons de qualit\u00e9 optimale<\/p>\n<\/div><div class=\"fusion-text fusion-text-3\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>R\u00e9sum\u00e9 (en anglais):<\/strong><\/p>\n<\/div><style type='text\/css'>.reading-box-container-2 .element-bottomshadow:before,.reading-box-container-2 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-2\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p>Cardiac allograft vasculopathy (CAV) is a leading contributor to graft loss and mortality in patients undergoing a heart transplant, with no curative options available and few strategies for prevention. In CAV, the recipient\u2019s immune system appears to attack the vessels of the newly placed heart, eventually leading to severe dysfunction which can give the patient a heart attack. Why CAV occurs is currently unknown. Our novel study will assess for the first time the potential role of cardioplegia, a required solution that is injected into the heart during procurement, in degrading a protective layer called the glycocalyx that normally coats the heart\u2019s vessels. This protective layer has a role in stopping the recipient\u2019s immune system from sensing the new heart, which can help prevent rejection and help mitigate CAV. Previous studies have shown that this protective layer can be disturbed by the fluids that are provided to the patient during surgery, however none have acknowledged that the cardioplegia solution can also act in a similar fashion to degrade this protective layer. In our study, we will see whether cardioplegia contributes to breaking down the glycocalyx, and we will compare different types of cardioplegia solution to see if certain ingredients can better preserve this protective layer during procurement. By investigating novel formulations of cardioplegia, we can develop better strategies that help protect the vessels of heart transplant recipients so they experience less rejection, and get to keep the heart they\u2019ve received for longer.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h5 class=\"fusion-responsive-typography-calculated\" style=\"text-align: center;\" data-fontsize=\"20\" data-lineheight=\"30px\"><strong><a href=\"https:\/\/cdtrp.ca\/fr\/resultats-du-concours-2024-de-subventions-pour-linnovation-en-recherche-du-prdtc-8-nouveaux-projets-finances\/\">Consultez tous les gagnants du Concours 2024 de subventions \u00e0 la recherche et l\u2019innovation du PRDTC.<\/a><\/strong><\/h5>\n<h5 class=\"\" style=\"text-align: center;\" data-fontsize=\"20\" data-lineheight=\"30px\"><a href=\"https:\/\/cdtrp.ca\/fr\/concours-innovation-prdtc-laureats\/\">Voyez les anciens laur\u00e9ats des subventions \u00e0 l\u2019innovation du PRDTC ici.<\/a><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":29207,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-29219","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/29219"}],"collection":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/comments?post=29219"}],"version-history":[{"count":4,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/29219\/revisions"}],"predecessor-version":[{"id":29223,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/29219\/revisions\/29223"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media\/29207"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media?parent=29219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/categories?post=29219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/tags?post=29219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}