{"id":24888,"date":"2023-07-18T08:01:52","date_gmt":"2023-07-18T13:01:52","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=24888"},"modified":"2023-07-24T09:43:53","modified_gmt":"2023-07-24T14:43:53","slug":"bourse-innovation-2023-blayne-amir-sayed","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/fr\/bourse-innovation-2023-blayne-amir-sayed\/","title":{"rendered":"Bourse d&rsquo;innovation en recherche PRDTC SickKids : Dr Blayne Amir Sayed"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1024\" height=\"576\" title=\"CDTRP Innovation Grant 2023 &#8211; Sayed\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2023\/07\/CDTRP-Innovation-Grant-2023-Sayed_FR.png\" alt class=\"lazyload img-responsive wp-image-24874\"\/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><h4 data-pm-slice=\"1 1 &#091;&#093;\"><strong>R\u00e9sultats du Concours 2023 de subventions pour l\u2019innovation en recherche du PRDTC<\/strong><\/h4>\n<p>Le PRDTC est ravi d&rsquo;annoncer les r\u00e9sultats du <a href=\"https:\/\/cdtrp.ca\/fr\/support-a-la-recherche\/concours-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Concours 2023 de subventions pour l\u2019innovation en recherche<\/a>, rendu possible gr\u00e2ce \u00e0 des partenariats avec diverses organisations. Nous sommes fiers de pr\u00e9senter tous les projets innovants qui ont \u00e9t\u00e9 financ\u00e9s dans le cadre du concours de cette ann\u00e9e.<\/p>\n<p>Nous tenons \u00e0 f\u00e9liciter chaleureusement le <strong>Dr Blayne Amir Sayed<\/strong> et son \u00e9quipe pour avoir re\u00e7u la <strong>bourse d&rsquo;innovation en recherche PRDTC SickKids<\/strong>. Nous leur souhaitons tout le succ\u00e8s possible dans la r\u00e9alisation de leur projet novateur !<\/p>\n<blockquote>\n<p data-pm-slice=\"1 1 &#091;&#093;\">\u00ab F\u00e9licitations au Dr Sayed ; le Centre de transplantation et de m\u00e9decine r\u00e9g\u00e9n\u00e9rative de SickKids est heureux de collaborer avec le PRDTC pour soutenir cette importante recherche sur la fa\u00e7on de r\u00e9duire les dommages pro-inflammatoires afin de limiter les l\u00e9sions d&rsquo;isch\u00e9mie-reperfusion du foie. Nous sommes impatients de conna\u00eetre les r\u00e9sultats de ces travaux et leur impact potentiel sur la r\u00e9duction des l\u00e9sions tissulaires lors de transplantations h\u00e9patiques. \u00bb<\/p>\n<p data-pm-slice=\"1 1 &#091;&#093;\"><strong>&#8211; Dr Upton Allen, directeur m\u00e9dical int\u00e9rimaire, Centre de transplantation et de m\u00e9decine r\u00e9g\u00e9n\u00e9rative de SickKids<\/strong><\/p>\n<\/blockquote>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\"><h5 data-pm-slice=\"1 1 &#091;&#093;\" data-fontsize=\"24\" data-lineheight=\"36px\">Bourse d&rsquo;innovation en recherche PRDTC SickKids : Dr Blayne Amir Sayed<\/h5>\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em><strong>Reduction of proinflammatory damage to limit liver ischemia-reperfusion injury\u00a0<\/strong><\/em><\/p>\n<ul>\n<li><strong>Affiliation principale : <\/strong>The Hospital for Sick Children Research Institute<\/li>\n<li><strong>Th\u00e8me 3<\/strong> &#8211; Des greffons de qualit\u00e9 optimale<\/li>\n<\/ul>\n<h6><strong>R\u00e9sum\u00e9e (en anglais)<\/strong><\/h6>\n<blockquote>\n<p data-pm-slice=\"1 1 &#091;&#093;\">Only fifty percent of Canadians on the waitlist i n 2020 for liver transplantation received a transplant that year. This trend of insufficient number of organs available for the number of patients in need is projected to worsen. However, we are limited by the number of suitable livers that are available to transplant. To increase the number of usable livers, we need to have the ability to salvage and improve the function of more marginal organs. We have identified a novel strategy for inhibiting an essential protein involved in cell rupture induced by stress similar to what occurs during liver transplantation. This targeted therapy prevents a significant proportion of cellular and tissue injury in an animal model of liver injury. Interestingly, we still see an independent inflammatory pathway occurring despite this successful inhibition. We suspect that a more complete liver protection could be obtained by utilizing a combinatorial approach: inhibiting cell rupture AND the upstream inflammatory mediators. Our objective is to investigate this approach using a mouse model of liver injury that we have expertise with. If successful, we believe we will have identified a foundational cellular strategy that will directly lead to a translatable approach in minimizing tissue injury during liver transplantation.<\/p>\n<\/blockquote>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3\"><h5 style=\"text-align: center;\"><strong><a href=\"https:\/\/cdtrp.ca\/fr\/concours-innovation-2023-resultats\/\">Consultez tous les gagnants du Concours 2023 de subventions \u00e0 la recherche et l\u2019innovation du PRDTC.<\/a><\/strong><\/h5>\n<h5 class=\"fusion-responsive-typography-calculated\" style=\"text-align: center;\" data-fontsize=\"20\" data-lineheight=\"30px\"><a href=\"https:\/\/cdtrp.ca\/fr\/concours-innovation-prdtc-laureats\/\">Voyez les anciens laur\u00e9ats des subventions \u00e0 l\u2019innovation du PRDTC ici.<\/a><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":24872,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81,37],"tags":[],"class_list":["post-24888","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-en-vedette","category-non-classifiee"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/24888"}],"collection":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/comments?post=24888"}],"version-history":[{"count":7,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/24888\/revisions"}],"predecessor-version":[{"id":25026,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/24888\/revisions\/25026"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media\/24872"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media?parent=24888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/categories?post=24888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/tags?post=24888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}