{"id":18603,"date":"2022-07-19T07:19:47","date_gmt":"2022-07-19T12:19:47","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=18603"},"modified":"2023-07-04T08:39:21","modified_gmt":"2023-07-04T13:39:21","slug":"bourse-innovation-marcelo-cypel","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/fr\/bourse-innovation-marcelo-cypel\/","title":{"rendered":"Bourse CDTRP Research Innovation &#8211; Dr Marcelo Cypel"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1600\" height=\"900\" title=\"2022 Innovation Grant Winner_Cypel\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2022\/07\/2022-Innovation-Grant-Winner_Cypel_FR.png\" alt class=\"lazyload img-responsive wp-image-18605\"\/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><h4 data-pm-slice=\"1 1 &#091;&#093;\">Bourse CDTRP Research Innovation &#8211; Dr Marcelo Cypel<\/h4>\n<p data-pm-slice=\"1 1 &#091;&#093;\">Gr\u00e2ce \u00e0 sa collaboration avec des organisations partenaires, le PRDTC est heureux d&rsquo;annoncer les r\u00e9sultats de son <a href=\"https:\/\/cdtrp.ca\/fr\/support-a-la-recherche\/concours-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Concours annuel de subventions \u00e0 la recherche et \u00e0 l\u2019innovation<\/a> visant \u00e0 financer de nouveaux projets passionnants. Au cours des prochaines semaines, nous pr\u00e9senterons tous les projets financ\u00e9s dans le cadre du concours 2022.<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\"><h5 data-pm-slice=\"1 1 &#091;&#093;\" data-fontsize=\"24\" data-lineheight=\"36px\"><strong>Bourse CDTRP Research Innovation\u00a0<\/strong><\/h5>\n<p data-pm-slice=\"1 1 &#091;&#093;\" data-fontsize=\"24\" data-lineheight=\"36px\"><strong>Dr Marcelo Cypel<\/strong><\/p>\n<ul>\n<li>Affiliation principale : University Health Network<\/li>\n<li>Th\u00e8me 3 &#8211; Des greffons de qualit\u00e9 optimale<\/li>\n<li>Titre : <em><strong>Ex-vivo immuno-cloaking of donor lungs to prevent transplant rejection: a proof of concept study<\/strong><\/em><\/li>\n<\/ul>\n<h6><strong>R\u00e9sum\u00e9 (en anglais)<\/strong><\/h6>\n<p><em>Lungs have the poorest outcome of all solid organ transplants, of about 50-60% survival rate within the first five years. Part of the reason are due to poor strategies to prevent immune-mediated rejection (patient\u2019s immune system attacks the new lung), and ischemia reperfusion injury (injuries that occur while reviving the lung). These injuries can result in primary graft dysfunction (PGD), a severe form of lung injury that is a major cause of early mortality. Early injuries and rejection are thought to start at the blood vessels as it is the first contact point between the transplanted lung and the patient. Starting from lung retrieval, all the way to transplant, the blood vessels are injured by the damage\/loss of the glycocalyx, a molecule that coats the cells of the blood vessels acting as a physical barrier. Our collaborator, Dr. Kizhakkedathu in a recent publication, showcased that reconstructing the organ\u2019s blood vessels with immunosuppressive polymers before transplantation prevents immune-mediated rejection without use of immunosuppressant. Based on these promising results, in collaboration with Dr. Kizhakkedathu, the current project aims to apply this polymer for lung transplantations. We will optimize the technology and evaluate the efficacy and safety with cell culture model and small animal model for lung specific uses. Results from this study will serve as basis for future translation into large animal and human clinical evaluation. Ultimately, successful translation of this new immune therapy from bend to bedside can help improve health benefits of millions of transplant patients in Canada and beyond.<\/em><\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:10px;margin-bottom:10px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-3\"><blockquote>\n<p data-pm-slice=\"1 1 &#091;&#093;\">\u00ab F\u00e9licitations au Dr Cypel et \u00e0 toute l&rsquo;\u00e9quipe pour ce projet passionnant, que le PRDTC est fier de soutenir. Ce travail est un parfait exemple de la fa\u00e7on dont la r\u00e9union de plusieurs disciplines peut conduire \u00e0 des id\u00e9es nouvelles et cr\u00e9atives pour r\u00e9soudre certains des plus grands d\u00e9fis de la transplantation. \u00bb<\/p>\n<\/blockquote>\n<p style=\"padding-left: 40px;\" data-pm-slice=\"1 1 &#091;&#093;\">&#8211; <strong>Dre Patricia Gongal<\/strong>, Directrice g\u00e9n\u00e9rale du PRDTC<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h5 style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/fr\/resultats-concours-2022-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Consultez tous les gagnants du Concours 2022 de subventions \u00e0 la recherche et l\u2019innovation du PRDTC.<\/a><\/h5>\n<h5 style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/fr\/concours-innovation-prdtc-laureats\/\">Consultez les anciens laur\u00e9ats ici.<\/a><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":18667,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81,37],"tags":[],"class_list":["post-18603","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-en-vedette","category-non-classifiee"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/18603"}],"collection":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/comments?post=18603"}],"version-history":[{"count":4,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/18603\/revisions"}],"predecessor-version":[{"id":24738,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/18603\/revisions\/24738"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media\/18667"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media?parent=18603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/categories?post=18603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/tags?post=18603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}