{"id":12490,"date":"2021-09-07T10:51:31","date_gmt":"2021-09-07T15:51:31","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=12490"},"modified":"2021-09-07T10:51:31","modified_gmt":"2021-09-07T15:51:31","slug":"recipiendaire-de-la-bourse-transplant-research-foundation-of-bc-cdtrp-venture-david-harriman","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/fr\/recipiendaire-de-la-bourse-transplant-research-foundation-of-bc-cdtrp-venture-david-harriman\/","title":{"rendered":"R\u00e9cipiendaire de la bourse Transplant Research Foundation of BC\/CDTRP Venture &#8211; Urine Microbiome Profiling in Kidney Transplant Recipients in Health and Disease (David Harriman)"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1024\" height=\"576\" title=\"CDTRP Innovation grant 2021_Harriman_FR\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/09\/CDTRP-Innovation-grant-2021_Harriman_FR.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/09\/CDTRP-Innovation-grant-2021_Harriman_FR-1024x576.png\" alt class=\"lazyload img-responsive wp-image-12492\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272240%27%20height%3D%271260%27%20viewBox%3D%270%200%202240%201260%27%3E%3Crect%20width%3D%272240%27%20height%3D%271260%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/09\/CDTRP-Innovation-grant-2021_Harriman_FR-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/09\/CDTRP-Innovation-grant-2021_Harriman_FR-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/09\/CDTRP-Innovation-grant-2021_Harriman_FR-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/09\/CDTRP-Innovation-grant-2021_Harriman_FR-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/09\/CDTRP-Innovation-grant-2021_Harriman_FR-1200x675.png 1200w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-1\"><h4>R\u00e9cipiendaire de la bourse Transplant Research Foundation of BC\/CDTRP Venture &#8211; Urine Microbiome Profiling in Kidney Transplant Recipients in Health and Disease (David Harriman)<\/h4>\n<p data-pm-slice=\"1 1 &#091;&#093;\">Gr\u00e2ce \u00e0 sa collaboration avec des organisations partenaires, le PRDTC est heureux d&rsquo;offrir son <a href=\"https:\/\/cdtrp.ca\/fr\/support-a-la-recherche\/concours-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Concours de subventions \u00e0 la recherche et l\u2019innovation<\/a> pour financer de nouvelles id\u00e9es de projets passionnants. Au cours des prochaines semaines, nous pr\u00e9senterons tous les projets financ\u00e9s dans le cadre du concours de 2021.<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\"><h4 data-pm-slice=\"1 1 &#091;&#093;\">Financ\u00e9 gr\u00e2ce \u00e0<strong> Transplant Research Foundation of BC\/CDTRP Venture Grant<\/strong><\/h4>\n<p><strong>Titre : <em>Urine Microbiome Profiling in Kidney Transplant Recipients in Health and Disease<\/em><\/strong><\/p>\n<ul>\n<li>Chercheur principal : David Harriman<\/li>\n<li>Principale affiliation : University of British Columbia<\/li>\n<li>Th\u00e8me 4<\/li>\n<\/ul>\n<h5>R\u00e9sum\u00e9 (en anglais)<\/h5>\n<p><em>Kidney transplant represents the best treatment for those with end stage renal disease, however transplant recipients have weakened immune systems secondary to anti-rejection medications that are necessary to prevent organ rejection with subsequent failure. Recently, specific bacterial communities have been found to reside in the urinary tract which may influence the immune system, the so-called urinary microbiome. The urinary microbiome has not been extensively investigated in kidney transplant patients, which presents a knowledge gap that we hope to address. Our goal is to understand the role urinary bacteria play in renal transplant patients and their associated influence on the transplanted kidney and the immune system. We hypothesize that urinary bacteria will directly influence the transplant kidney and may participate in maintaining or exacerbating the health of that kidney. To validate this hypothesis, we will test adult and pediatric renal transplant recipient urine, with associated clinical information, to determine bacterial compositions that live in the urine in both healthy post-transplant states and during kidney transplant rejection using state of the art laboratory techniques (16S rRNA sequencing). Furthermore, we will specifically assess the urine bacterial environments of male and female patients, as there have been reported differences in the urinary microbiome based on gender related to hormonal and anatomic considerations in non-transplant patients. If successful, this study will pave the way for future projects aimed at developing tools to identify and halt kidney transplant injury so that transplant recipients can maintain their health for as long as possible.<\/em><\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3\"><p style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/fr\/resultats-du-concours-2021-de-subventions-a-la-recherche-et-linnovation-du-prdtc-11-nouveaux-projets-finances\/\">Consultez les r\u00e9sultats du Concours 2021 de subventions \u00e0 la recherche et l\u2019innovation du PRDTC<\/a>.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/fr\/anciens-laureats-des-concours-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Consultez les anciens laur\u00e9ats du Concours de subventions \u00e0 la recherche et l\u2019innovation du PRDTC.<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":12492,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81,37],"tags":[],"class_list":["post-12490","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-en-vedette","category-non-classifiee"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/12490"}],"collection":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/comments?post=12490"}],"version-history":[{"count":5,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/12490\/revisions"}],"predecessor-version":[{"id":12552,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/12490\/revisions\/12552"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media\/12492"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media?parent=12490"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/categories?post=12490"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/tags?post=12490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}