{"id":11943,"date":"2021-07-20T07:38:12","date_gmt":"2021-07-20T12:38:12","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=11943"},"modified":"2023-07-04T08:54:48","modified_gmt":"2023-07-04T13:54:48","slug":"recipiendaire-bourse-cdtrp-uhn-research-innovation-ana-konvalinka","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/fr\/recipiendaire-bourse-cdtrp-uhn-research-innovation-ana-konvalinka\/","title":{"rendered":"R\u00e9cipiendaire de la bourse CDTRP UHN Research Innovation &#8211; Investigating Kidney Tissue Responses to Donor Specific Antibodies in Antibody Mediated Rejection (Ana Konvalinka)"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1024\" height=\"576\" title=\"CDTRP Innovation grant 2021_Ana Konvalinka_FR\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CDTRP-Innovation-grant-2021_Ana-Konvalinka_FR.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CDTRP-Innovation-grant-2021_Ana-Konvalinka_FR-1024x576.png\" alt class=\"lazyload img-responsive wp-image-12111\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272240%27%20height%3D%271260%27%20viewBox%3D%270%200%202240%201260%27%3E%3Crect%20width%3D%272240%27%20height%3D%271260%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CDTRP-Innovation-grant-2021_Ana-Konvalinka_FR-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CDTRP-Innovation-grant-2021_Ana-Konvalinka_FR-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CDTRP-Innovation-grant-2021_Ana-Konvalinka_FR-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CDTRP-Innovation-grant-2021_Ana-Konvalinka_FR-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CDTRP-Innovation-grant-2021_Ana-Konvalinka_FR-1200x675.png 1200w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-1\"><h4>R\u00e9cipiendaire de la bourse CDTRP UHN Research Innovation &#8211; Investigating Kidney Tissue Responses to Donor Specific Antibodies in Antibody Mediated Rejection (Ana Konvalinka)<\/h4>\n<p data-pm-slice=\"1 1 &#091;&#093;\">Gr\u00e2ce \u00e0 sa collaboration avec des organisations partenaires, le PRDTC est heureux d&rsquo;offrir son <a href=\"https:\/\/cdtrp.ca\/fr\/support-a-la-recherche\/concours-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Concours de subventions \u00e0 la recherche et l\u2019innovation<\/a> pour financer de nouvelles id\u00e9es de projets passionnants. Au cours des prochaines semaines, nous pr\u00e9senterons tous les projets financ\u00e9s dans le cadre du concours de 2021.<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\"><h4>Projet financ\u00e9 gr\u00e2ce \u00e0 <em><strong>CDTRP UHN Research Innovation Grant <\/strong><\/em>:<\/h4>\n<p><strong>Titre : <em>Investigating<\/em><\/strong><em><strong> Kidney Tissue Responses to Donor Specific Antibodies in Antibody Mediated Rejection<\/strong><\/em><\/p>\n<ul>\n<li>Chercheuse principale : Ana Konvalinka<\/li>\n<li>Principale affiliation : University Health Network<\/li>\n<li>Th\u00e8me 5<\/li>\n<li>\u00c9quipe : Igor Jurisica, Rohan John, Stephen Juvet<\/li>\n<\/ul>\n<h5>R\u00e9sum\u00e9 (en anglais)<\/h5>\n<p><em><strong>PURPOSE:<\/strong> Kidney transplantation is the best treatment for end-stage kidney disease. However, most kidneys fail prematurely. The main cause of premature graft loss is antibody-mediated rejection (AMR), which is caused by antibodies against the donor that activate immune cells. Surprisingly, these antibodies cause rejection in about half of patients who develop them, while other patients tolerate them without developing rejection. Our goal is to study kidney tissue effects of antibodies that cause rejection compared to those that do not, in order to determine how to treat AMR better.<\/em><\/p>\n<p><em><strong>PROCEDURE:<\/strong> We will use innovative methods to study the consequences of antibody interactions with the immune cells. First, we will determine the effect of the antibodies on the kidney, from biopsies of patients with AMR. Second, we will identify immune cells present in kidneys with AMR compared to kidneys that did not develop AMR despite the presence of antibodies. We will examine the receptors that these immune cells use to respond to the antibodies.<\/em><\/p>\n<p><em><strong>OUTCOME:<\/strong> We expect to find that antibodies that caused AMR, compared to those that did not, will more readily activate and recruit immune cells in the kidney graft. We will be able to define details underpinning these differences and relate them to kidney injury.<\/em><\/p>\n<p><em><strong>RELEVANCE TO PATIENTS:<\/strong> Our project will determine the effects of harmful antibodies on the kidney AMR. Future studies may improve the lives of patients, because we may identify potential ways to treat AMR, which is the most important reason for premature kidney transplant loss.<\/em><\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3\"><p style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/fr\/resultats-du-concours-2021-de-subventions-a-la-recherche-et-linnovation-du-prdtc-11-nouveaux-projets-finances\/\">Consultez les r\u00e9sultats du Concours 2021 de subventions \u00e0 la recherche et l\u2019innovation du PRDTC<\/a>.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/fr\/concours-innovation-prdtc-laureats\/\">Consultez les anciens laur\u00e9ats du Concours de subventions \u00e0 la recherche et l\u2019innovation du PRDTC.<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":12111,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81,37],"tags":[],"class_list":["post-11943","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-en-vedette","category-non-classifiee"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/11943"}],"collection":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/comments?post=11943"}],"version-history":[{"count":7,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/11943\/revisions"}],"predecessor-version":[{"id":24761,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/11943\/revisions\/24761"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media\/12111"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media?parent=11943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/categories?post=11943"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/tags?post=11943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}