{"id":11937,"date":"2021-07-20T07:33:49","date_gmt":"2021-07-20T12:33:49","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=11937"},"modified":"2021-07-20T07:39:40","modified_gmt":"2021-07-20T12:39:40","slug":"recipiendaire-de-la-bourse-transplant-research-foundation-of-bc-cdtrp-venture-caigan-du","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/fr\/recipiendaire-de-la-bourse-transplant-research-foundation-of-bc-cdtrp-venture-caigan-du\/","title":{"rendered":"R\u00e9cipiendaire de la bourse Transplant Research Foundation of BC\/CDTRP Venture &#8211;  Evaluation of propyl gallate for limitation of cold ischemic injury in organ preservation (Caigan Du)"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1024\" height=\"576\" title=\"CDTRP Innovation grant 2021_CaiganDu\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272240%27%20height%3D%271260%27%20viewBox%3D%270%200%202240%201260%27%3E%3Crect%20width%3D%272240%27%20height%3D%271260%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CDTRP-Innovation-grant-2021_CaiganDu_FR.png\" alt class=\"lazyload img-responsive wp-image-11939\"\/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-1\"><h4>R\u00e9cipiendaire de la bourse Transplant Research Foundation of BC\/CDTRP Venture\u00a0&#8211; Evaluation of propyl gallate for limitation of cold ischemic injury in organ preservation (Caigan Du)<\/h4>\n<p data-pm-slice=\"1 1 &#091;&#093;\">Gr\u00e2ce \u00e0 sa collaboration avec des organisations partenaires, le PRDTC est heureux d&rsquo;offrir son <a href=\"https:\/\/cdtrp.ca\/fr\/support-a-la-recherche\/concours-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Concours de subventions \u00e0 la recherche et l\u2019innovation<\/a> pour financer de nouvelles id\u00e9es de projets passionnants. Au cours des prochaines semaines, nous pr\u00e9senterons tous les projets financ\u00e9s dans le cadre du concours de 2021.<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\"><h4 data-pm-slice=\"1 1 &#091;&#093;\">Projet financ\u00e9 gr\u00e2ce \u00e0 une bourse <em><strong>Transplant Research Foundation of BC\/CDTRP Venture <\/strong><\/em>:<\/h4>\n<p><strong>Titre : <\/strong><em><strong>Evaluation of propyl gallate for limitation of cold ischemic injury in organ preservation<\/strong><\/em><\/p>\n<ul>\n<li>Chercheur principal : Caigain Du<\/li>\n<li>Principale affiliation : Universit\u00e9 de Colombie-Britannique<\/li>\n<li>Th\u00e8me 3<\/li>\n<li>\u00c9quipe : Christopher Nguan<\/li>\n<\/ul>\n<h5>R\u00e9sum\u00e9 (en anglais)<\/h5>\n<p><em>Organ transplantation starts from a surgical procedure &#8211; removing an organ from a donor body and then implanting it into a recipient. However, cells of the donor organ die immediately after the blood supply is disrupted; thus, the donor organ must be perfused and stored in a cold preservation solution to control its damage. There are several preservation solutions available, but none of them performs ideally, particularly in the preservation of the deceased donors because a large number (up to 50%) of them don&rsquo;t not work properly after transplantation. As a result, it increases the health care cost of transplant patients, shortens implanted organ survival and limits use of those deceased donors. Our objective is to develop a better cold preservation solution based on a novel hyperbranched polyglycerol and propyl gallate. Our preliminary studies show that the HPG-based preservation solution protects the organs to be transplanted superior to any of the current methods available. Addition of propyl gallate to this HPG solution or standard University of Wisconsin (UW) solution further prevents cell death in three different human cells. In this proposal, we will use a preclinical model to confirm the increased prevention of donor kidney injury by addition of propyl gallate to the organ preservation solution. We anticipate that the success of this project will have significant impact: on patient\u2019s recovery after surgery; increasing the donor pool to benefit more Canadians who need a transplant to save their life; and will translate to significant savings to Canadian health care system.<\/em><\/p>\n<p>Pour en savoir plus sur Caigan, un nouveau membre du PRDTC, <a href=\"https:\/\/cdtrp.ca\/fr\/profil-de-nouveau-membre-dr-caigan-du-professeur-associe-et-specialiste-des-reins-a-lubc\/\">cliquez ici<\/a>.<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3\"><p style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/fr\/resultats-du-concours-2021-de-subventions-a-la-recherche-et-linnovation-du-prdtc-11-nouveaux-projets-finances\/\">Consultez les r\u00e9sultats du Concours 2021 de subventions \u00e0 la recherche et l\u2019innovation du PRDTC<\/a>.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/fr\/anciens-laureats-des-concours-de-subventions-a-la-recherche-et-linnovation-du-prdtc\/\">Consultez les anciens laur\u00e9ats du Concours de subventions \u00e0 la recherche et l\u2019innovation du PRDTC.<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":11982,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81,37],"tags":[],"class_list":["post-11937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-en-vedette","category-non-classifiee"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/11937"}],"collection":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/comments?post=11937"}],"version-history":[{"count":11,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/11937\/revisions"}],"predecessor-version":[{"id":12027,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/posts\/11937\/revisions\/12027"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media\/11982"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/media?parent=11937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/categories?post=11937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/fr\/wp-json\/wp\/v2\/tags?post=11937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}