{"id":21582,"date":"2023-01-26T09:59:02","date_gmt":"2023-01-26T14:59:02","guid":{"rendered":"https:\/\/cdtrp.ca\/en\/?post_type=spucpt&#038;p=21582"},"modified":"2023-01-26T09:59:02","modified_gmt":"2023-01-26T14:59:02","slug":"lius-webinar","status":"publish","type":"spucpt","link":"https:\/\/cdtrp.ca\/en\/spucpt\/lius-webinar\/","title":{"rendered":"Liu&#8217;s webinar"},"content":{"rendered":"<p><strong>Molecular mechanisms and therapeutic targets of human lung transplant injury<\/strong><\/p>\n<p>Cold preservation and warm reperfusion are unavoidable steps of organ transplantation. These dramatic changes add stresses to the grafts, induce so called ischemia-reperfusion injury that led to primary graft dysfunction. To study the underlying mechanisms, animal models and clinical observations are the major tools. Over the past twenty years, we have developed a tissue bank to collect specimens from lung tissues, EVLP perfusate, patients\u2019 plasma and bronchoalveolar lavage fluid. Recently, we used these samples to study the expression of genes (transcriptomics), proteins (proteomics), and metabolites (metabolomics). Omics is the way to study all the targeted molecules all together, in order to figure out the underlying pathways and mechanisms. These studies revealed important mechanisms that can be used as targets for develop new therapeutics.<\/p>\n<p><em>Original title: Omics and ischemia-reperfusion injury in human lung transplants<\/em><\/p>\n","protected":false},"author":6,"template":"","class_list":["post-21582","spucpt","type-spucpt","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/spucpt\/21582","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/spucpt"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/spucpt"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/6"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=21582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}