{"id":20275,"date":"2022-10-26T13:20:20","date_gmt":"2022-10-26T18:20:20","guid":{"rendered":"https:\/\/cdtrp.ca\/en\/?post_type=spucpt&p=20275"},"modified":"2022-11-24T10:11:29","modified_gmt":"2022-11-24T15:11:29","slug":"emmanuel-nogueira-3mt","status":"publish","type":"spucpt","link":"https:\/\/cdtrp.ca\/en\/spucpt\/emmanuel-nogueira-3mt\/","title":{"rendered":"Emmanuel Nogueira 3MT"},"content":{"rendered":"

Emmanuel Nogueira’s bio<\/strong><\/p>\n

\"\"<\/p>\n

Dr. Emmanuel Nogueira attended the Federal University of Cear\u00e1 (UFC),graduating in 2013 with a medical degree. Following that, he became a fellow at the Federal University of Ceara of Scientific Initiation in Liver Transplantation, and completed both his general surgery at the Onofre Lopes University Hospital of the Federal University of Rio Grande do Norte, Brazil, from 2015 to 2017, and his medical residency in digestive tract surgery at the general hospital in Fortaleza, Cear\u00e1, Brazil, from 2017 to 2019. Serving as the team surgeon for the liver transplantation program at the General Hospital of Fortaleza and So Camilo Hospital in Fortaleza, CE, Brazil in 2019, and as the project leader at Sao Camilo’s Hospital, a pioneering operation, for two years while carrying out roughly 40 liver transplants, he has plenty of experience performing and mentoring clinical research groups with great success. In 2020, he started a master of science degree in transplantation at the State University of Ceara, focusing on research in organ preservation. Dr. Emmanuel Nogueira not only has a remarkable medical past, but he also continues to pursue an ongoing education and professional development with the Toronto Organ Preservation Laboratory in Toronto General Hospital.<\/p>\n

\n

Use of Pancaspase inhibitor during Normothermic ex vivo liver perfusion: a strategy to reduce ischemia reperfusion injury in pig liver grafts<\/strong><\/p>\n

Yuki Noguchi, Masataka Kawamura, Catherine Parmentier, Samrat Ray<\/em>
\nBhranavi Arulratnam, Sujani Ganesh, Nazia Selzner, Trevor Reichman, Markus Selzner<\/em><\/p>\n

Background: Ischemia-reperfusion injury (IRI) has significant impact in Liver Transplant (LTx) especially for expanded criteria donors, such as cardiac death donors (DCD). IRI is mainly induced by apoptosis which is regulated by caspases cascade. Caspases are proteolytic enzymes responsible for cell death and activation of inflammatory cytokines. Normothermic ex-vivo liver perfusion (NEVLP) emerges as an important tool to reduce the impact of IRI. NEVLP reduces liver tissue damage caused by cold ischemia, but also allows the development of strategies for better organ preservation, such as the use of nutrients, hormones and drugs which, acting directly on the liver, can improve graft function after transplant. In this study we used a porcine model for NEVLP applying Emricasan, a pancaspase inhibitor, during NEVLP to assess its effects on liver function and tissue damage.<\/p>\n

Methods: A model for Porcine DCD retrieval was used with 60 min of warm ischemia followed by 5 hrs of NEVLP. The swine were divided into two groups: the EMRICASAN group (n=4) and the CONTROL group (n=4). Primary endpoints were liver injury and function during perfusion.<\/p>\n

Results: AST levels were significantly reduced in the Emricasan treated vs the control group (p=0.0004). Bile glucose levels were higher in Emricasan group (p&lt;0,0001). Improvement in liver weight and bile production were observed with Emricasan treatment that did not reach significance. Liver and bile pH levels, bile bicarbonate, hepatic artery and portal vein flow showed no differences between the two groups.<\/p>\n

Conclusion: The pancaspase inhibitor Emricasan demonstrated potential benefit in reducing tissue damage and enhancing liver function during NEVLP in a donor model with increased ischemic damage. Emricasan administration during NEVLP may be a new strategy to reduce IRI after liver transplant.<\/p>\n","protected":false},"author":6,"template":"","class_list":["post-20275","spucpt","type-spucpt","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/spucpt\/20275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/spucpt"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/spucpt"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/6"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=20275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}