{"id":20228,"date":"2022-10-26T11:45:43","date_gmt":"2022-10-26T16:45:43","guid":{"rendered":"https:\/\/cdtrp.ca\/en\/?post_type=spucpt&p=20228"},"modified":"2022-10-26T11:45:43","modified_gmt":"2022-10-26T16:45:43","slug":"imane-kaci-3mt","status":"publish","type":"spucpt","link":"https:\/\/cdtrp.ca\/en\/spucpt\/imane-kaci-3mt\/","title":{"rendered":"Imane Kaci 3MT"},"content":{"rendered":"

Imane Kaci’s bio<\/strong><\/p>\n

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Imane Kaci is a Ph.D. student in the Nephrology, Transplantation and Renal\u00a0Regeneration Research Unit at the CHUM Research Centre in Montreal. She is also an academic trainee in the Canadian Donation and Transplantation Research Program (CDTRP). She completed an MSc degree in Molecular Pathology and Personalized Medicine at Universit\u00e9 de Montr\u00e9al. She then joined the laboratory of Dr Marie-Jos\u00e9e H\u00e9bert to pursue her Ph.D. in Molecular Biology. Her research project focuses on understanding the immune response triggered by apoptotic exosome-like vesicles released by apoptotic endothelial cells, and its impact on microvascular rarefaction, renal fibrosis, and kidney function loss after renal ischemia-reperfusion injury in transplanted and native kidneys.<\/p>\n

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Apoptotic exosome-like vesicles mediate immune response dysregulation and kidney dysfunction following ischemia-reperfusion injury<\/strong><\/p>\n

Kidneys clean the blood and dispose of the waste produced by the body\u2019s cells in the urine. They have abundant blood vessels providing them with oxygen and nutrients to function. Kidney function decreases when injuring its smallest blood vessels, especially in old people. We showed that damaging these vessels during transplantation causes kidney graft to fail. We discovered that injured vessels release pieces of cell, called \u2018ApoExo\u2019, in the blood. ApoExo activate the immune system to produce antibodies attacking damaged kidneys. We found these antibodies in the blood of kidney recipients with poor graft function. We now study how ApoExo alter immune response causing renal failure and graft rejection. We used mice with injured kidneys mimicking what transplant procedure causes in patients. We collected kidney and blood to measure ApoExo, immune response, and kidney damage. We found that injured kidney releases more ApoExo with age, which increases immune system activation. This induces more antibodies and white blood cells to attack kidneys’ smallest vessels. It then perpetuates ApoExo release and worsens kidney damage and function. Our study gives a new vision of immunological mechanisms causing renal graft impairment. It will help to better preserve donor\u2019s kidney and make it last longer in patients.<\/p>\n","protected":false},"author":6,"template":"","class_list":["post-20228","spucpt","type-spucpt","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/spucpt\/20228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/spucpt"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/spucpt"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/6"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=20228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}