{"id":6277,"date":"2020-08-04T13:40:24","date_gmt":"2020-08-04T13:40:24","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=6277"},"modified":"2020-08-24T12:31:24","modified_gmt":"2020-08-24T12:31:24","slug":"spotlight-paper-impact-of-apoptotic-exosome-like-vesicles-on-endothelial-cell-function","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/spotlight-paper-impact-of-apoptotic-exosome-like-vesicles-on-endothelial-cell-function\/","title":{"rendered":"Spotlight Paper: Impact of apoptotic exosome-like vesicles on endothelial cell function"},"content":{"rendered":"

Spotlight Paper: Impact of apoptotic exosome-like vesicles on endothelial cell function<\/h4>\n

The CDTRP would like to congratulate Marie-Jos\u00e9e H\u00e9bert, Francis Migneault, M\u00e9lanie Dieud\u00e9, Julie Turgeon and all the other collaborators who have been working on the paper “Apoptotic exosome\u2011like vesicles regulate endothelial gene expression, inflammatory signaling, and function through the NF\u2011\u03baB signaling pathway<\/strong>“, recently published in Nature – Scientific Reports!<\/span><\/p>\n

A great team effort on the impact of apoptotic exosome-like vesicles on endothelial cell function.<\/span><\/p>\n

Abstract<\/h5>\n

Persistent endothelial injury promotes maladaptive responses by favoring the release of factors leading to perturbation in vascular homeostasis and tissue architecture. Caspase-3 dependent death of microvascular endothelial cells leads to the release of unique apoptotic exosome-like vesicles (ApoExo). Here, we evaluate the impact of ApoExo on endothelial gene expression and function in the context of a pro-apoptotic stimulus. Endothelial cells exposed to ApoExo differentially express genes involved in cell death, inflammation, differentiation, and cell movement. Endothelial cells exposed to ApoExo showed inhibition of apoptosis, improved wound closure along with reduced angiogenic activity and reduced expression of endothelial markers consistent with the first phase of endothelial-to-mesenchymal transition (endoMT). ApoExo interaction with endothelial cells also led to NF-\u03baB activation. NF-\u03baB is known to participate in endothelial dysfunction in numerous diseases. Silencing NF-\u03baB reversed the anti-apoptotic effect and the pro-migratory state and prevented angiostatic properties and CD31 downregulation in endothelial cells exposed to ApoExo. This study identifies vascular injury-derived extracellular vesicles (ApoExo) as novel drivers of NF-\u03baB activation in endothelial cells and demonstrates the pivotal role of this signaling pathway in coordinating ApoExo-induced functional changes in endothelial cells. Hence, targeting ApoExo-mediated NF-\u03baB activation in endothelial cells opens new avenues to prevent endothelial dysfunction.<\/span><\/p>\n

You can read the article here<\/a>.<\/h5>\n<\/div>
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