{"id":34996,"date":"2026-10-13T21:09:32","date_gmt":"2026-10-14T01:09:32","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=34996"},"modified":"2026-10-13T21:12:49","modified_gmt":"2026-10-14T01:12:49","slug":"cdtrp-kfoc-research-innovation-grant-dr-paraish-misra","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/cdtrp-kfoc-research-innovation-grant-dr-paraish-misra\/","title":{"rendered":"CDTRP KFOC Research Innovation Grant : Dr. Paraish Misra"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1600\" height=\"900\" title=\"2026 Innovation Grant_KFOC_ Winners\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant_KFOC_-Winners.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant_KFOC_-Winners.png\" alt class=\"lazyload img-responsive wp-image-34981\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant_KFOC_-Winners-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant_KFOC_-Winners-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant_KFOC_-Winners-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant_KFOC_-Winners-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant_KFOC_-Winners-1200x675.png 1200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2026\/10\/2026-Innovation-Grant_KFOC_-Winners.png 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>CDTRP 2026 Research Innovation Grant Competition Results<\/strong><\/p>\n<p>CDTRP is thrilled to announce the results of the <a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/en\/announcing-the-results-of-the-2026-cdtrp-research-innovation-grant-competition-7-new-projects-funded\/\">CDTRP 2026 Research Innovation Grant Competition<\/a>, made possible through our partnership with various esteemed organizations. We are proud to showcase all of the exciting projects that have been funded in this year\u2019s competition.<\/p>\n<p>We would like to extend our warmest congratulations to <strong>Dr. Paraish Misra<\/strong> and his team for being awarded the <strong>CDTRP KFOC Research Innovation Grant<\/strong>. We wish them all the best as they embark on their innovative project!<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><style type='text\/css'>.reading-box-container-1 .element-bottomshadow:before,.reading-box-container-1 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-1\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em>&#8220;The Kidney Foundation of Canada is excited to support this work which could see immunosuppression after transplantation as a thing of the past. While transplantation can provide a new outlook on life for many kidney patients, it is often accompanied by a lifelong complications resultant from the requirement to take medications to suppress the host immune system. Innovation that could contribute to the reduction of immunosuppressive medications, have the potential to result in meaningful change for the post transplant community, and increase the potential for transplant as a treatment in a larger percentage of the population.&#8221;<\/em><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>CDTRP KFOC Research Innovation Grant<\/strong> <strong>: Dr. Paraish Misra<\/strong><\/p>\n<p><strong>Project Title: <\/strong>Personalized immunomodulation after kidney transplant using donor-derived thymic epithelial cells<\/p>\n<p><strong>Main affiliation: <\/strong>McGill University<\/p>\n<p><strong>Theme: 4 \u2013 <\/strong>Tailor an Optimal Immune System for Each Patient<\/p>\n<\/div><div class=\"fusion-text fusion-text-3\"><p><span style=\"color: #000000;\"><strong>Lay Abstract<\/strong><\/span><\/p>\n<\/div><style type='text\/css'>.reading-box-container-2 .element-bottomshadow:before,.reading-box-container-2 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-2\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\">Kidney transplants give people their lives back, but powerful drugs called immunosuppressants are needed to prevent the immune system from rejecting the organ. These medications are a double-edged sword &#8211; they increase the risk of infections, cancer, and other complications and still do not work perfectly for everyone. Because of these risks, some people are considered too frail for a transplant, and for those who do get transplanted, these drugs cannot be stopped without risking rejection.<\/p>\n<p>This project explores a new way to protect kidney transplants without using immunosuppressants. I will collect cells that are naturally shed into the urine of transplant recipients. These cells come from the donor kidney and carry the donor\u2019s genetic identity. After collecting these cells, I will convert them into induced pluripotent stem cells (iPSCs), a flexible cell type that can be grown into any tissue in the body. I will then guide these iPSCs to become thymic cells. The thymus is an organ that \u201ctrains\u201d immune cells to recognize which tissues are part of the body and which are foreign.<\/p>\n<p>My long\u2011term goal is to use this lab-grown donor thymus to \u201cre\u2011educate\u201d the immune system so it accepts the transplanted kidney as its own. If this works, it could one day reduce the amount of immunosuppressants people need, and possibly allow some patients to stop them altogether. This would make treatment easier, improve quality of life, and may allow more people, especially those who are older or medically fragile, to safely receive kidney transplants.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h5 style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/en\/announcing-the-results-of-the-2026-cdtrp-research-innovation-grant-competition-7-new-projects-funded\/\"><strong>View the results of the 2026 CDTRP Research Innovation Grant Competition.<\/strong><\/a><\/h5>\n<h5 class=\"fusion-responsive-typography-calculated\" style=\"text-align: center;\" data-fontsize=\"20\" data-lineheight=\"30px\"><a href=\"https:\/\/cdtrp.ca\/en\/cdtrp-innovation-grant-winners\/\">View past CDTRP Innovation Grants recipients here.<\/a><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":34981,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,75],"tags":[],"class_list":["post-34996","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","category-featured"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/34996","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/comments?post=34996"}],"version-history":[{"count":3,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/34996\/revisions"}],"predecessor-version":[{"id":34999,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/34996\/revisions\/34999"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media\/34981"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=34996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/categories?post=34996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/tags?post=34996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}