{"id":32916,"date":"2025-08-18T23:28:20","date_gmt":"2025-08-19T03:28:20","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=32916"},"modified":"2025-08-19T08:32:03","modified_gmt":"2025-08-19T12:32:03","slug":"cdtrp-lhsc-research-innovation-grant-dr-zhu-xu-zhang","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/cdtrp-lhsc-research-innovation-grant-dr-zhu-xu-zhang\/","title":{"rendered":"CDTRP LHSC Research Innovation Grant: Dr. Zhu-Xu Zhang"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1600\" height=\"900\" title=\"Dr. Zhu-Xu Zhang\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/Dr.-Zhu-Xu-Zhang.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/Dr.-Zhu-Xu-Zhang.png\" alt class=\"lazyload img-responsive wp-image-32920\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/Dr.-Zhu-Xu-Zhang-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/Dr.-Zhu-Xu-Zhang-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/Dr.-Zhu-Xu-Zhang-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/Dr.-Zhu-Xu-Zhang-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/Dr.-Zhu-Xu-Zhang-1200x675.png 1200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/Dr.-Zhu-Xu-Zhang.png 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>CDTRP 2025 Research Innovation Grant Competition Results<\/strong><\/p>\n<p>CDTRP is thrilled to announce the results of the <a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/en\/announcing-the-results-of-the-2025-cdtrp-research-innovation-grant-competition-11-new-projects-funded\/\">CDTRP 2025 Research Innovation Grant Competition<\/a>, made possible through our partnership with various esteemed organizations. We are proud to showcase all of the exciting projects that have been funded in this year\u2019s competition.<\/p>\n<p>We would like to extend our warmest congratulations to <strong>Dr. Zhu-Xu Zhang<\/strong> and his team for being awarded the <strong>CDTRP LHSC Research Innovation Grant<\/strong>. We wish them all the best as they embark on their innovative project!<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><style type='text\/css'>.reading-box-container-1 .element-bottomshadow:before,.reading-box-container-1 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-1\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em>The Multi-Organ Transplant Program at London Health Sciences Centre has a long and proud history of supporting innovation and research, which directly contributes to improved care and quality of life for our patients.\u00a0 We are especially proud of Dr. Zhu-Xu Zhang, who research project \u201cThe Potential of Inhibiting Multiple Cell Death Pathways in Transplantation\u201d holds promise of significantly enhancing transplant success and patient outcomes.<\/em><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>CDTRP LHSC Research Innovation Grant<\/strong>\u00a0<strong>: Dr. Zhu-Xu Zhang<\/strong><\/p>\n<p><strong>Project Title: <\/strong>The potential of inhibiting multiple cell death pathways in transplantation<\/p>\n<p><strong>Main affiliation: <\/strong>London Health Sciences Centre Research Institute<\/p>\n<p><strong>Theme: 3 \u2013 <\/strong>Engineer and Allocate Better Grafts<\/p>\n<\/div><div class=\"fusion-text fusion-text-3\"><p><span style=\"color: #000000;\"><strong>Lay Abstract<\/strong><\/span><\/p>\n<\/div><style type='text\/css'>.reading-box-container-2 .element-bottomshadow:before,.reading-box-container-2 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-2\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\">When a heart is irreversibly damaged and cannot be treated by any other medical or surgical means, organ transplantation is the most beneficial and highly pursued treatment option for saving the person&#8217;s life. However, the immune system of the graft recipient usually recognizes the transplant as a \u2018stranger\u2019, leading to organ rejection. Additionally, organ donor shortage is a devastating challenge in transplantation. 80% of transplants use deceased donor organs, and 20% use living donor organs. Unfortunately, most deceased donor organs are discarded because of extended injury, while 40% of patients on the organ waiting list have died. Novel therapeutic strategies are urgently required to preserve heart function and improve clinical outcomes.<\/p>\n<p>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Inflammation post-transplantation induces different &#8220;&#8221;forms&#8221;&#8221; of cell death and, subsequently, organ failure. We have revealed that multi-cell death pathways are activated simultaneously in the graft post-transplantation and contribute to acute and chronic transplant damage. However, these multi-cell death pathways are not affected by current anti-rejection drugs. We have recently found a strategy to block cell death and attenuate acute graft injury in mouse heart transplantation. In this grant, we will explore if targeting cell death molecular components offers a potential for therapeutic development to reduce short- and long-term damage in heart transplantation. Furthermore, we will identify molecules that control multiple cell death pathways in patient samples. Thus, these studies will guide future clinical therapies for inflammation and may lead to truly novel approaches for preventing transplanted heart graft injury and rejection in patients.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h5 style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/en\/announcing-the-results-of-the-2025-cdtrp-research-innovation-grant-competition-11-new-projects-funded\/\"><strong>View the results of the 2025 CDTRP Research Innovation Grant Competition.<\/strong><\/a><\/h5>\n<h5 class=\"fusion-responsive-typography-calculated\" style=\"text-align: center;\" data-fontsize=\"20\" data-lineheight=\"30px\"><a href=\"https:\/\/cdtrp.ca\/en\/cdtrp-innovation-grant-winners\/\">View past CDTRP Innovation Grants recipients here.<\/a><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":32920,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,75],"tags":[],"class_list":["post-32916","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","category-featured"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/32916"}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/comments?post=32916"}],"version-history":[{"count":2,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/32916\/revisions"}],"predecessor-version":[{"id":32934,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/32916\/revisions\/32934"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media\/32920"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=32916"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/categories?post=32916"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/tags?post=32916"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}