{"id":32825,"date":"2025-08-11T09:37:26","date_gmt":"2025-08-11T13:37:26","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=32825"},"modified":"2025-08-12T11:25:33","modified_gmt":"2025-08-12T15:25:33","slug":"organ-donation-and-transplant-research-foundation-of-bc-cdtrp-venture-grant-dr-sonny-thiara-and-dr-mypinder-sekhon","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/organ-donation-and-transplant-research-foundation-of-bc-cdtrp-venture-grant-dr-sonny-thiara-and-dr-mypinder-sekhon\/","title":{"rendered":"Organ Donation and Transplant Research Foundation of BC\/CDTRP Venture Grant\u00a0: Dr. Sonny Thiara and Dr. Mypinder Sekhon"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1600\" height=\"900\" title=\"Thiara&#038;Sekhoon\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/ThiaraSekhoon-2.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/ThiaraSekhoon-2.png\" alt class=\"lazyload img-responsive wp-image-32884\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/ThiaraSekhoon-2-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/ThiaraSekhoon-2-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/ThiaraSekhoon-2-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/ThiaraSekhoon-2-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/ThiaraSekhoon-2-1200x675.png 1200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2025\/08\/ThiaraSekhoon-2.png 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>CDTRP 2025 Research Innovation Grant Competition Results<\/strong><\/p>\n<p data-pm-slice=\"1 1 &#091;&#093;\">CDTRP is thrilled to announce the results of the <a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/en\/announcing-the-results-of-the-2025-cdtrp-research-innovation-grant-competition-11-new-projects-funded\/\">CDTRP 2025 Research Innovation Grant Competition<\/a>, made possible through our partnership with various esteemed organizations. We are proud to showcase all of the exciting projects that have been funded in this year\u2019s competition.<\/p>\n<p>We would like to extend our warmest congratulations to <strong>Dr. Sonny Thiara and Dr. Mypinder Sekhon<\/strong> and their team for being awarded the <strong>Organ Donation and Transplant Research Foundation of BC\/CDTRP Venture Grant<\/strong>. We wish them all the best as they embark on their innovative project!<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><style type='text\/css'>.reading-box-container-1 .element-bottomshadow:before,.reading-box-container-1 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-1\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em>\u201cWe are proud to support these bold and innovative projects that address critical gaps in organ donation and transplantation research. From improving neurologic death prediction to advancing organ viability through perfusion science and elevating patient and physician voices in kidney transplantation, each project reflects our commitment to discovery, collaboration, and meaningful impact.\u201d<\/em><\/p>\n<p><em>Rachael Durie, ODTRF Co-Chair<\/em><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>Organ Donation and Transplant Research Foundation of BC\/CDTRP Venture Grant<\/strong>\u00a0<strong>: Dr. Sonny Thiara and Dr. Mypinder Sekhon<\/strong><\/p>\n<p><strong>Project Title: <\/strong>Neurologic Biomarker Guided Prediction of Time to Death Determination in Donation after Circulatory Death Donors<\/p>\n<p><strong>Main affiliation: <\/strong>University of British Columbia<\/p>\n<p><strong>Theme: 2 \u2013 <\/strong>Inform Universal Practices for Donation<\/p>\n<\/div><div class=\"fusion-text fusion-text-3\"><p><span style=\"color: #000000;\"><strong>Lay Abstract<\/strong><\/span><\/p>\n<\/div><style type='text\/css'>.reading-box-container-2 .element-bottomshadow:before,.reading-box-container-2 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-2\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\">Organ donation can only commence once death has been declared in a potential donor, however, the prediction of how quickly death will occur following removal of life support interventions is very unclear. Further, the longer the duration between the removal of life support and death declaration, the more the potential organs that are eligible to be transplanted become injured from low blood flow and oxygen levels during the dying process. The prediction of the dying duration, trajectory and whether or not organ donation will be successful is extremely limited. Robust, generalizable and reproducible methods for this prediction are needed to inform donation and transplant teams as well as patients and their families.<\/p>\n<p>The brain controls various vital functions of the human body. Relative to organ donation, severe brain dysfunction can accelerate the dying duration by leading to upper airway compromise or by leading to decreased heart function (because the brain controls the heart\u2019s internal drive). Quantifying and assessing these dynamics in prospective organ donors is an essential step to develop a clinical prediction tool.<\/p>\n<p>We will conduct a multicenter prospective observational study to assess our ability to use non-invasive brain blood tests to predict the time to death in organ donors.\u00a0 Specifically, we will assess our ability to conduct these blood tests across multiple hospitals in Canada and whether their accuracy in predicting the dying duration is equivalent across institutions. Using these non-invasive, generalizable and pragmatic blood tests we will create a new and novel prediction tool of the dying duration and will assess it against the currently available modest prediction variables and &#8220;&#8221;physician gestalt&#8221;&#8221;.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h5 style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/en\/announcing-the-results-of-the-2025-cdtrp-research-innovation-grant-competition-11-new-projects-funded\/\"><strong>View the results of the 2025 CDTRP Research Innovation Grant Competition.<\/strong><\/a><\/h5>\n<h5 class=\"fusion-responsive-typography-calculated\" style=\"text-align: center;\" data-fontsize=\"20\" data-lineheight=\"30px\"><a href=\"https:\/\/cdtrp.ca\/en\/cdtrp-innovation-grant-winners\/\">View past CDTRP Innovation Grants recipients here.<\/a><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":32884,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,75],"tags":[],"class_list":["post-32825","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","category-featured"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/32825"}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/comments?post=32825"}],"version-history":[{"count":2,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/32825\/revisions"}],"predecessor-version":[{"id":32890,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/32825\/revisions\/32890"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media\/32884"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=32825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/categories?post=32825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/tags?post=32825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}