{"id":29697,"date":"2024-09-13T11:12:52","date_gmt":"2024-09-13T15:12:52","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=29697"},"modified":"2024-09-13T11:12:52","modified_gmt":"2024-09-13T15:12:52","slug":"cdtrp-udem-research-innovation-grant-dr-caroline-lemarche","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/cdtrp-udem-research-innovation-grant-dr-caroline-lemarche\/","title":{"rendered":"CDTRP UdeM Research Innovation Grant: Dr. Caroline Lemarche"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1600\" height=\"900\" alt=\"2024 Innovation Grant Winner: Dr. Caroline Lamarche\" title=\"Lamarche EN\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-EN.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-EN.png\" class=\"lazyload img-responsive wp-image-29702\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-EN-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-EN-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-EN-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-EN-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-EN-1200x675.png 1200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/09\/Lamarche-EN.png 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p data-pm-slice=\"1 1 &#091;&#093;\"><span style=\"color: #000000;\"><strong>CDTRP 2024 Research Innovation Grant Competition Results<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\">CDTRP is thrilled to announce the results of the <span style=\"color: #0000ff;\"><a class=\"ProsemirrorEditor-link\" style=\"color: #0000ff;\" href=\"https:\/\/cdtrp.ca\/en\/support-for-research\/cdtrp-innovation-grant-competition\/\">CDTRP 2024 Research Innovation Grant Competition<\/a><\/span>, made possible through our partnership with various esteemed organizations. We are proud to showcase all of the exciting projects that have been funded in this year\u2019s competition.<\/span><\/p>\n<p data-pm-slice=\"1 1 &#091;&#093;\"><span style=\"color: #000000;\">We would like to extend our warmest congratulations to <strong>Dr. Caroline Lamarche<\/strong> and her team for being awarded the <strong>CDTRP UdeM Research Innovation Grant<\/strong>. We wish them all the best as they embark on their innovative project!<\/span><\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><style type='text\/css'>.reading-box-container-1 .element-bottomshadow:before,.reading-box-container-1 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-1\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em>The Transplantation Program of the Universit\u00e9 de Montr\u00e9al would like to congratulate Dr. Caroline Lamarche on winning the CDTRP innovation grant in the 2024 competition for her project entitled &#8220;Tacrolimus-resistant regulatory T cells for adoptive immunotherapy&#8221;. The Transplantation Program of the Universit\u00e9 de Montr\u00e9al is proud to contribute to the CDTRP grant competitions and thus participate in transplantation and organ donation research in Canada.<\/em><\/p>\n<p><em>The 2 projects funded by a CDTRP Universit\u00e9 de Montr\u00e9al grant illustrate the mission of the Transplantation Program of the Universit\u00e9 de Montr\u00e9al, which is to support innovation in research and clinical practice in order to improve the care of transplanted donors, families and patients.<\/em><\/p>\n<p><em>-Transplantation Program of the Universit\u00e9 de Montr\u00e9al<\/em><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p data-pm-slice=\"1 1 &#091;&#093;\"><span style=\"color: #000000;\"><strong>CDTRP UdeM Research Innovation Grant<\/strong>\u00a0<strong>: Dr. Caroline Lamarche<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Project Title: <\/strong>Tacrolimus-resistant regulatory T cells for adoptive immunotherapy<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Main affiliation: <\/strong>Universit\u00e9 de Montr\u00e9al<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Theme: 4 &#8211; <\/strong>Tailor an Optimal Immune System for Each Patient<\/span><\/p>\n<\/div><div class=\"fusion-text fusion-text-3\"><p><span style=\"color: #000000;\"><strong>Lay Abstract<\/strong><\/span><\/p>\n<\/div><style type='text\/css'>.reading-box-container-2 .element-bottomshadow:before,.reading-box-container-2 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-2\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\">Transplantation save lives. However, patients need to take anti-rejection drugs. Those drugs come with many side effects. For example, they increase the risk of cardiovascular diseases, infection and cancer. In the last decade, an alternative to those anti-rejection drugs has emerge. It is the injection of regulatory T cells (Tregs), the good cells of the immune system. We collect white blood cells (immune cells) from a transplant recipient. Then, we isolate the good guys (Tregs) and grow them in a laboratory. Finally, the cells are re-infused to the same patient. This was shown to be safe and doable. It allows to decrease the number of anti-rejection drugs. However, most patients still need to take tacrolimus, one of the anti-regection drug. Unfortunately, this drug also affect the good cells (Tregs) we injected. Our goal here is to modify Tregs to make them resistant to tacrolimus. Our study will have to main aims.<\/p>\n<p>First, we will study in detail the impact of tacrolimus on Tregs, the good cells. Then, we will modify the Tregs genetically, making them tacrolimus-resistant. We will show that it is possible and study the impact on the cells. The ultimate goal would be to develop this technique and bring it to a clinical trial. If Tregs are resistant to tacrolimus, it could make them more effective. Indeed, they might survive longer or grow more in patients after injection.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h5 style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/en\/announcing-the-results-of-the-2024-cdtrp-research-innovation-grant-competition-8-new-projects-funded\/\"><strong>View the results of the 2024 CDTRP Research Innovation Grant Competition.<\/strong><\/a><\/h5>\n<h5 class=\"fusion-responsive-typography-calculated\" style=\"text-align: center;\" data-fontsize=\"20\" data-lineheight=\"30px\"><a href=\"https:\/\/cdtrp.ca\/en\/cdtrp-innovation-grant-winners\/\">View past CDTRP Innovation Grants recipients here.<\/a><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":29702,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,75],"tags":[],"class_list":["post-29697","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","category-featured"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/29697"}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/comments?post=29697"}],"version-history":[{"count":1,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/29697\/revisions"}],"predecessor-version":[{"id":29706,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/29697\/revisions\/29706"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media\/29702"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=29697"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/categories?post=29697"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/tags?post=29697"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}