{"id":29205,"date":"2024-08-06T10:25:57","date_gmt":"2024-08-06T14:25:57","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=29205"},"modified":"2024-08-06T10:25:57","modified_gmt":"2024-08-06T14:25:57","slug":"cdtrp-research-innovation-grant-dr-darren-freed","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/cdtrp-research-innovation-grant-dr-darren-freed\/","title":{"rendered":"CDTRP Research Innovation Grant: Dr. Darren Freed"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1600\" height=\"900\" title=\"CDTRP Innovation Grants 2024 &#8211; Freed EN\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-EN.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-EN.png\" alt class=\"lazyload img-responsive wp-image-29209\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-EN-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-EN-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-EN-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-EN-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-EN-1200x675.png 1200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2024\/08\/CDTRP-Innovation-Grants-2024-Freed-EN.png 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><h4 data-pm-slice=\"1 1 &#091;&#093;\"><strong>CDTRP 2024 Research Innovation Grant Competition Results<\/strong><\/h4>\n<p data-pm-slice=\"1 1 &#091;&#093;\">CDTRP is thrilled to announce the results of the <a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/en\/support-for-research\/cdtrp-innovation-grant-competition\/\">CDTRP 2024 Research Innovation Grant Competition<\/a>, made possible through our partnership with various esteemed organizations. We are proud to showcase all of the exciting projects that have been funded in this year\u2019s competition.<\/p>\n<p>We would like to extend our warmest congratulations to <strong>Dr. Darren Freed<\/strong> and his team for being awarded the <strong>CDTRP ATI\/Paladin Research Innovation Grant<\/strong>. We wish them all the best as they embark on their innovative project!<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><style type='text\/css'>.reading-box-container-1 .element-bottomshadow:before,.reading-box-container-1 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-1\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em>&#8220;We congratulate Dr. Darren Freed, a member of the Alberta Transplant Institute, on securing the 2024 CDTRP ATI\/Paladin Research Innovation Grant. Optimizing protocols in heart procurement is critical given the scarcity of donor organs. We eagerly anticipate the results of your research on \u201cEndothelial Glycocalyx Integrity During Heart Procurement: Impact of Crystalloid Solutions\u201d and its impact on advancing heart transplantation outcomes.<\/em><\/p>\n<p><em>Once again, congratulations, and we wish you the best in your research endeavors!&#8221;<\/em><\/p>\n<p><em><strong>&#8211; Alberta Transplant Institute<\/strong><\/em><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p data-pm-slice=\"1 1 &#091;&#093;\"><strong>CDTRP ATI\/Paladin Research Innovation Grant: Darren Freed<\/strong><\/p>\n<p>Endothelial glycocalyx integrity during heart procurement: impact of crystalloid solutions<\/p>\n<p><strong>Main affiliation:<\/strong> University of Alberta<\/p>\n<p><strong>Theme: 3<\/strong> &#8211; Engineer and Allocate Better Grafts<\/p>\n<\/div><div class=\"fusion-text fusion-text-3\"><p><strong>Lay Abstract<\/strong><\/p>\n<\/div><style type='text\/css'>.reading-box-container-2 .element-bottomshadow:before,.reading-box-container-2 .element-bottomshadow:after{opacity:0.7;}<\/style><div class=\"fusion-reading-box-container reading-box-container-2\" style=\"--awb-title-color:#333c4e;--awb-margin-top:0px;--awb-margin-bottom:84px;\"><div class=\"reading-box\" style=\"background-color:#f6f6f6;border-width:1px;border-color:#f6f6f6;border-left-width:3px;border-left-color:var(--primary_color);border-style:solid;\"><div class=\"reading-box-additional\">\n<p>Cardiac allograft vasculopathy (CAV) is a leading contributor to graft loss and mortality in patients undergoing a heart transplant, with no curative options available and few strategies for prevention. In CAV, the recipient\u2019s immune system appears to attack the vessels of the newly placed heart, eventually leading to severe dysfunction which can give the patient a heart attack. Why CAV occurs is currently unknown. Our novel study will assess for the first time the potential role of cardioplegia, a required solution that is injected into the heart during procurement, in degrading a protective layer called the glycocalyx that normally coats the heart\u2019s vessels. This protective layer has a role in stopping the recipient\u2019s immune system from sensing the new heart, which can help prevent rejection and help mitigate CAV. Previous studies have shown that this protective layer can be disturbed by the fluids that are provided to the patient during surgery, however none have acknowledged that the cardioplegia solution can also act in a similar fashion to degrade this protective layer. In our study, we will see whether cardioplegia contributes to breaking down the glycocalyx, and we will compare different types of cardioplegia solution to see if certain ingredients can better preserve this protective layer during procurement. By investigating novel formulations of cardioplegia, we can develop better strategies that help protect the vessels of heart transplant recipients so they experience less rejection, and get to keep the heart they\u2019ve received for longer.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h5 style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/en\/announcing-the-results-of-the-2024-cdtrp-research-innovation-grant-competition-8-new-projects-funded\/\"><strong>View the results of the 2024 CDTRP Research Innovation Grant Competition.<\/strong><\/a><\/h5>\n<h5 class=\"fusion-responsive-typography-calculated\" style=\"text-align: center;\" data-fontsize=\"20\" data-lineheight=\"30px\"><a href=\"https:\/\/cdtrp.ca\/en\/cdtrp-innovation-grant-winners\/\">View past CDTRP Innovation Grants recipients here.<\/a><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":29209,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,75],"tags":[],"class_list":["post-29205","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","category-featured"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/29205"}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/comments?post=29205"}],"version-history":[{"count":8,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/29205\/revisions"}],"predecessor-version":[{"id":29217,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/29205\/revisions\/29217"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media\/29209"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=29205"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/categories?post=29205"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/tags?post=29205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}