{"id":24887,"date":"2023-07-18T08:00:28","date_gmt":"2023-07-18T13:00:28","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=24887"},"modified":"2023-07-18T08:00:28","modified_gmt":"2023-07-18T13:00:28","slug":"innovation-grant-2023-blayne-amir-sayed","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/innovation-grant-2023-blayne-amir-sayed\/","title":{"rendered":"CDTRP SickKids Research Innovation Grant: Dr. Blayne Amir Sayed"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1024\" height=\"576\" title=\"CDTRP Innovation Grant 2023 &#8211; Sayed\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2023\/07\/CDTRP-Innovation-Grant-2023-Sayed.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2023\/07\/CDTRP-Innovation-Grant-2023-Sayed-1024x576.png\" alt class=\"lazyload img-responsive wp-image-24873\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%27900%27%20viewBox%3D%270%200%201600%20900%27%3E%3Crect%20width%3D%271600%27%20height%3D%27900%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2023\/07\/CDTRP-Innovation-Grant-2023-Sayed-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2023\/07\/CDTRP-Innovation-Grant-2023-Sayed-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2023\/07\/CDTRP-Innovation-Grant-2023-Sayed-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2023\/07\/CDTRP-Innovation-Grant-2023-Sayed-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2023\/07\/CDTRP-Innovation-Grant-2023-Sayed-1200x675.png 1200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2023\/07\/CDTRP-Innovation-Grant-2023-Sayed.png 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><h4 data-pm-slice=\"1 1 &#091;&#093;\"><strong>CDTRP 2023 Research Innovation Grant Competition Results<\/strong><\/h4>\n<p class=\"sc-98942fc5-0 JcSiB\" data-testid=\"youchat-text\">CDTRP is thrilled to announce the results of the <a href=\"https:\/\/cdtrp.ca\/en\/support-for-research\/cdtrp-innovation-grant-competition\/\">CDTRP 2023 Research Innovation Grant Competition<\/a>, made possible through our partnership with various esteemed organizations. We are proud to showcase all of the exciting projects that have been funded in this year&#8217;s competition.<\/p>\n<p class=\"sc-98942fc5-0 JcSiB\" data-testid=\"youchat-text\">We would like to extend our warmest congratulations to <strong>Dr. Blayne Amir Sayed<\/strong> and his team for being awarded the <strong>CDTRP SickKids Research Innovation Grant<\/strong>. We wish them all the best as they embark on their innovative project!<\/p>\n<blockquote>\n<p data-pm-slice=\"1 1 &#091;&#093;\">\u201cCongratulations to Dr. Sayed; the SickKids Transplant and Regenerative Medicine Centre is pleased to collaborate with the CDTRP to support this important research investigating how to reduce proinflammatory damage to limit liver ischemia-reperfusion injury. We look forward to hearing the results of this work and its potential impact in minimizing tissue injury during liver transplantation.\u201d<\/p>\n<p data-pm-slice=\"1 1 &#091;&#093;\"><strong>&#8211; Dr. Upton Allen, Interim Medical Director, SickKids Transplant and Regenerative Medicine Centre<\/strong><\/p>\n<\/blockquote>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\"><h5 data-pm-slice=\"1 1 &#091;&#093;\" data-fontsize=\"24\" data-lineheight=\"36px\"><strong>CDTRP SickKids Research Innovation Grant: Dr. Blayne Amir Sayed <\/strong><\/h5>\n<p data-pm-slice=\"1 1 &#091;&#093;\"><strong>Reduction of proinflammatory damage to limit liver ischemia-reperfusion injury\u00a0<\/strong><\/p>\n<ul>\n<li><strong>Main affiliation: <\/strong>The Hospital for Sick Children Research Institute<\/li>\n<li><strong>Theme 3<\/strong> &#8211; Engineer and Allocate Better Grafts<\/li>\n<\/ul>\n<h6><strong>Lay abstract<\/strong><\/h6>\n<blockquote>\n<p data-pm-slice=\"1 1 &#091;&#093;\">Only fifty percent of Canadians on the waitlist i n 2020 for liver transplantation received a transplant that year. This trend of insufficient number of organs available for the number of patients in need is projected to worsen. However, we are limited by the number of suitable livers that are available to transplant. To increase the number of usable livers, we need to have the ability to salvage and improve the function of more marginal organs. We have identified a novel strategy for inhibiting an essential protein involved in cell rupture induced by stress similar to what occurs during liver transplantation. This targeted therapy prevents a significant proportion of cellular and tissue injury in an animal model of liver injury. Interestingly, we still see an independent inflammatory pathway occurring despite this successful inhibition. We suspect that a more complete liver protection could be obtained by utilizing a combinatorial approach: inhibiting cell rupture AND the upstream inflammatory mediators. Our objective is to investigate this approach using a mouse model of liver injury that we have expertise with. If successful, we believe we will have identified a foundational cellular strategy that will directly lead to a translatable approach in minimizing tissue injury during liver transplantation.<\/p>\n<\/blockquote>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3\"><h5 style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/en\/innovation-grant-2023-results\/\"><strong>View the results of the 2023 CDTRP Research Innovation Grant Competition.<\/strong><\/a><\/h5>\n<h5 class=\"fusion-responsive-typography-calculated\" style=\"text-align: center;\" data-fontsize=\"20\" data-lineheight=\"30px\"><a href=\"https:\/\/cdtrp.ca\/en\/cdtrp-innovation-grant-winners\/\">View past CDTRP Innovation Grants recipients here.<\/a><\/h5>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":24873,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,75],"tags":[],"class_list":["post-24887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","category-featured"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/24887"}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/comments?post=24887"}],"version-history":[{"count":2,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/24887\/revisions"}],"predecessor-version":[{"id":24921,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/24887\/revisions\/24921"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media\/24873"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=24887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/categories?post=24887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/tags?post=24887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}