{"id":21712,"date":"2023-02-07T08:26:15","date_gmt":"2023-02-07T13:26:15","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=21712"},"modified":"2023-04-05T07:49:33","modified_gmt":"2023-04-05T12:49:33","slug":"research-connect-liu","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/research-connect-liu\/","title":{"rendered":"CDTRP Research Connect – Dr. Mingyao Liu"},"content":{"rendered":"

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CDTRP Research Connect Series<\/strong><\/h4>\n

The CDTRP is pleased to host its new discussion-based meeting series called “Research Connect<\/strong>“.<\/p>\n

This series streamlines the subset of Theme, Hub, and Working Group meetings that aimed to share and discuss the latest research findings across the network and our Webinar series, which featured national and international speakers. Theme, Hub, and Working Group meetings aimed at developing new initiatives, projects, or grants will be scheduled separately, approximately three times per year per group.<\/p>\n

The new series will occur bi-monthly, on Tuesdays at 1-2 pm EST.<\/strong><\/p>\n

Our goal is to make it easy for our members to know about and attend high quality presentations across all Themes and topics of interest. We are aiming for active discussions including researchers, trainees, and patient, family, and donor partners, engaging the whole community as if we were having a family dinner rather than listening to a formal presentation.<\/p>\n<\/div>

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<\/i>Visit the website<\/span><\/a><\/div><\/div><\/div><\/div><\/div>
Dr. Mingyao Liu: Molecular mechanisms and therapeutic targets of human lung transplant injury\u00a0<\/strong><\/h5>\n

On February 21, we were pleased to have Dr. Mingyao Liu<\/b> to present on the topic: “Molecular mechanisms and therapeutic targets of human lung transplant injury ” as part of the CDTRP Theme 3 – Engineer and Allocate Better Grafts.<\/p>\n<\/div>

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Description<\/strong><\/h5>\n

Cold preservation and warm reperfusion are unavoidable steps of organ transplantation. These dramatic changes add stresses to the grafts, induce so called ischemia-reperfusion injury that led to primary graft dysfunction. To study the underlying mechanisms, animal models and clinical observations are the major tools. Over the past twenty years, we have developed a tissue bank to collect specimens from lung tissues, EVLP perfusate, patients\u2019 plasma and bronchoalveolar lavage fluid. Recently, we used these samples to study the expression of genes (transcriptomics), proteins (proteomics), and metabolites (metabolomics). Omics is the way to study all the targeted molecules all together, in order to figure out the underlying pathways and mechanisms. These studies revealed important mechanisms that can be used as targets for develop new therapeutics.<\/p>\n<\/div>

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