{"id":12169,"date":"2021-08-03T09:58:01","date_gmt":"2021-08-03T14:58:01","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=12169"},"modified":"2023-07-04T08:53:03","modified_gmt":"2023-07-04T13:53:03","slug":"cdtrp-research-innovation-grant-awardee-corinne-hoesli-steven-paraskevas","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/cdtrp-research-innovation-grant-awardee-corinne-hoesli-steven-paraskevas\/","title":{"rendered":"CDTRP Research Innovation Grant awardee &#8211; Making every pancreatic islet count \u2013 engineering a vascularized transplantation system to treat type 1 diabetes (Corinne Hoesli &#038; Steven Paraskevas)"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><img decoding=\"async\" width=\"1024\" height=\"576\" title=\"CDTRP Innovation grant 2021_Hoesli_Paraskevas\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/08\/CDTRP-Innovation-grant-2021_Hoesli_Paraskevas.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/08\/CDTRP-Innovation-grant-2021_Hoesli_Paraskevas-1024x576.png\" alt class=\"lazyload img-responsive wp-image-12171\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272240%27%20height%3D%271260%27%20viewBox%3D%270%200%202240%201260%27%3E%3Crect%20width%3D%272240%27%20height%3D%271260%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/08\/CDTRP-Innovation-grant-2021_Hoesli_Paraskevas-200x113.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/08\/CDTRP-Innovation-grant-2021_Hoesli_Paraskevas-400x225.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/08\/CDTRP-Innovation-grant-2021_Hoesli_Paraskevas-600x338.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/08\/CDTRP-Innovation-grant-2021_Hoesli_Paraskevas-800x450.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/08\/CDTRP-Innovation-grant-2021_Hoesli_Paraskevas-1200x675.png 1200w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-1\"><h4>CDTRP Research Innovation Grant awardee &#8211; Making every pancreatic islet count \u2013 engineering a vascularized transplantation system to treat type 1 diabetes (Corinne Hoesli &amp; Steven Paraskevas)<\/h4>\n<p data-pm-slice=\"1 1 &#091;&#093;\">Through collaboration with partner organizations, CDTRP is pleased to offer our annual <a href=\"https:\/\/cdtrp.ca\/en\/support-for-research\/cdtrp-innovation-grant-competition\/\">Research Innovation Grant competition<\/a> to fund exciting new project ideas. Over the coming weeks, we will be profiling all of the projects funded in the 2021 competition.<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\"><h4 data-pm-slice=\"1 1 &#091;&#093;\">Funded through a <strong>CDTRP Research Innovation Grant<\/strong><\/h4>\n<p><strong>Title: Making every pancreatic islet count \u2013 engineering a vascularized transplantation system to treat type 1 diabetes<\/strong><\/p>\n<ul>\n<li>Principal investigators: Corinne Hoesli &amp; Steven Paraskevas<\/li>\n<li>Main affiliation: McGill University<\/li>\n<li>Part of Theme 3<\/li>\n<\/ul>\n<h5>Lay Abstract<\/h5>\n<p data-pm-slice=\"1 1 &#091;&#093;\">Type 1 diabetes (T1D) is an autoimmune disorder caused by the destruction of the insulin-producing beta cells of the pancreas. Insulin regulates blood glucose levels. Even with regular blood glucose monitoring and insulin administration, people with T1D experience significant challenges controlling blood glucose. Low blood glucose levels can lead to loss of conscience and even death, while high blood glucose levels are associated with long-term complications such as heart disease, loss of feeling in extremities and loss of vision. Instead of replacing the insulin hormone, the insulin-producing beta cells can be replaced through a procedure termed islet transplantation. Islet transplantation can avoid the need for insulin in 70% of recipients for at least 2 years and reduces the risks of hypoglycemia for several years. Unfortunately, this therapy is not accessible to most people with T1D due to limited cell supply from organ donors. Moreover, islet transplant recipients must take immune suppressive drugs for the rest of their lives after the procedure, increasing risks of infection and cancer. The objective of this project is to design a transplantation device that could be combined with a variety of islet cell sources, increasing access to the therapy. This islet encapsulation device would also protect the graft from the immune system, avoiding the need for immune suppression. Finally, the device would be retrievable if complications arise. While other encapsulation devices are being developed, a unique feature of our new device is the optimization of graft survival via short and long-term islet oxygenation.<\/p>\n<p data-pm-slice=\"1 1 &#091;&#093;\"><em><strong>\u00a0Interested in learning more? This project will be presented at the Theme 3 Meeting on August 18 (<a href=\"https:\/\/cdtrp.ca\/en\/theme-3-august-18-meeting-agenda\/\">more detail here<\/a>).<\/strong><\/em><\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3\"><p style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/en\/2021-cdtrp-research-innovation-grant-competition\/\">View the\u00a0results of the 2021 CDTRP Research Innovation Grant Competition<\/a><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/cdtrp.ca\/en\/cdtrp-innovation-grant-winners\/\">View past CDTRP Innovation Grants winners here.<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":12171,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,75],"tags":[],"class_list":["post-12169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","category-featured"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/12169"}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/comments?post=12169"}],"version-history":[{"count":3,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/12169\/revisions"}],"predecessor-version":[{"id":24757,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/12169\/revisions\/24757"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media\/12171"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=12169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/categories?post=12169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/tags?post=12169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}