{"id":12083,"date":"2021-07-27T07:42:26","date_gmt":"2021-07-27T12:42:26","guid":{"rendered":"https:\/\/cdtrp.ca\/?p=12083"},"modified":"2021-07-27T07:45:38","modified_gmt":"2021-07-27T12:45:38","slug":"launch-of-the-cinergy-trial","status":"publish","type":"post","link":"https:\/\/cdtrp.ca\/en\/launch-of-the-cinergy-trial\/","title":{"rendered":"Launch of the CINERGY Trial: linking donation and transplantation"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1 hover-type-none\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><a class=\"fusion-no-lightbox\" href=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CINERGY-Pilot-Trial_Newsletter1.pdf\" target=\"_self\" aria-label=\"Capture d\u2019e\u0301cran, le 2021-07-26 a\u0300 13.36.20\"><img decoding=\"async\" width=\"1024\" height=\"419\" src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/Capture-de\u0301cran-le-2021-07-26-a\u0300-13.36.20.png\" data-orig-src=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/Capture-de\u0301cran-le-2021-07-26-a\u0300-13.36.20-1024x419.png\" alt class=\"lazyload img-responsive wp-image-12095\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272134%27%20height%3D%27874%27%20viewBox%3D%270%200%202134%20874%27%3E%3Crect%20width%3D%272134%27%20height%3D%27874%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/Capture-de\u0301cran-le-2021-07-26-a\u0300-13.36.20-200x82.png 200w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/Capture-de\u0301cran-le-2021-07-26-a\u0300-13.36.20-400x164.png 400w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/Capture-de\u0301cran-le-2021-07-26-a\u0300-13.36.20-600x246.png 600w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/Capture-de\u0301cran-le-2021-07-26-a\u0300-13.36.20-800x328.png 800w, https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/Capture-de\u0301cran-le-2021-07-26-a\u0300-13.36.20-1200x491.png 1200w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/a><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-1\"><h4>Launch of the CINERGY Trial: linking donation and transplantation<\/h4>\n<p data-pm-slice=\"1 1 &#091;&#093;\">The <a class=\"ProsemirrorEditor-link\" href=\"https:\/\/cdtrp.ca\/en\/freshly-funded-congratulations-to-the-cinergy-team\/\">CINERGY Trial<\/a> has now received Health Canada approval, provincial REB approvals and CIHR funding to launch the first Canadian randomized controlled trial (RCT) that links donation and transplantation research.<\/p>\n<p>Lead PI Fr\u00e9d\u00e9rick D&#8217;Aragon, co-investigators Maureen Meade and Markus Selzner, and the whole team are excited to initiate this pilot trial and are\u00a0looking\u00a0forward to\u00a0a successful collaboration\u00a0of the transplantation and donation communities.<\/p>\n<ul>\n<li>The CINERGY Pilot RCT is establishing an avenue for the implementation of new innovations in organ protection that allows upstream donor interventions; strengthening a collaborative network between donor and recipient communities.<\/li>\n<\/ul>\n<ul>\n<li>CINERGY opens the door to \u201cengineering a better graft\u201d at a whole new level, starting upstream with interventions for organs prior to organ recovery.<\/li>\n<\/ul>\n<ul>\n<li>Donor intervention research is a promising path to reduce graft injury and increase the donor pool for our patients on the waiting list.<\/li>\n<\/ul>\n<p><em>To learn more about this work, contact Project Manager Ruth Breau at <u><a class=\"ProsemirrorEditor-link\" href=\"mailto:breaur@mcmaster.ca\">breaur@mcmaster.ca<\/a>.<\/u><\/em><\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;margin-bottom:20px;width:100%;\"><\/div><div style=\"text-align:center;\"><a class=\"fusion-button button-flat fusion-button-default-size button-custom fusion-button-default button-1 fusion-button-default-span fusion-button-default-type\" style=\"--button_accent_color:#ffffff;--button_border_color:#ffffff;--button_accent_hover_color:#edf2f7;--button_border_hover_color:#ffffff;--button_gradient_top_color:#aa0e13;--button_gradient_bottom_color:#aa0e13;--button_gradient_top_color_hover:#aa0e13;--button_gradient_bottom_color_hover:#aa0e13;--button_text_transform:uppercase;\" target=\"_self\" href=\"https:\/\/cdtrp.ca\/wp-content\/uploads\/2021\/07\/CINERGY-Pilot-Trial_Newsletter1.pdf\"><span class=\"fusion-button-text\">Download the brochure<\/span><\/a><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-double sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;border-bottom-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\"><h5><strong>CINERGY Lay Abstract<\/strong><\/h5>\n<p>In Canada, most life-saving transplants involve vital organs from deceased organ donors. When organs are removed from organ donors, they are transported with great care to transplant centres in other hospitals, or cities, and even distant provinces. Any interval in time in which a donated organ is preserved without blood circulation may result in organ injury. The time without blood flow can cause organ injury and the re-establishment of blood flow during transplantation may lead to severe injury, called ischemia reperfusion injury, or IR injury. IR injury threatens the viability of organ transplants in the short term, and the long term. Several treatments for transplant recipients aim to reduce the risk of IR injury.\u00a0 Similarly, there are treatments for the organ, itself, before transplant, that aim to mitigate IR injury. There are no treatments, however, provided to organ donors with a view to purpose of reducing IR jury and improving the health of organ transplant recipients. The CINERGY Pilot Trial, in Ontario and Quebec, will test the feasibility of a future national study that tests a drug for administered to organ donors to reduce IR injury in organ recipients. The drug is tacrolimus, a common transplant medication that has never been provided to organ donors. However, animal studies consistently suggest that the \u201cpreconditioning\u201d of organ donors with tacrolimus will improve transplant function.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":12095,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,75],"tags":[],"class_list":["post-12083","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","category-featured"],"_links":{"self":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/12083"}],"collection":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/comments?post=12083"}],"version-history":[{"count":7,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/12083\/revisions"}],"predecessor-version":[{"id":12154,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/posts\/12083\/revisions\/12154"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media\/12095"}],"wp:attachment":[{"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/media?parent=12083"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/categories?post=12083"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdtrp.ca\/en\/wp-json\/wp\/v2\/tags?post=12083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}