{"id":6108,"date":"2020-07-17T19:23:18","date_gmt":"2020-07-17T19:23:18","guid":{"rendered":"https:\/\/cdtrp.ca\/?page_id=6108"},"modified":"2021-01-26T21:03:30","modified_gmt":"2021-01-26T21:03:30","slug":"covid-19-ongoing-clinical-trials-donation-and-transplantation-focus","status":"publish","type":"page","link":"https:\/\/cdtrp.ca\/en\/publications\/covid-19-ongoing-clinical-trials-donation-and-transplantation-focus\/","title":{"rendered":"COVID-19 Ongoing Clinical Trials – Donation and Transplantation Focus"},"content":{"rendered":"

Canadian Blood Services, the Canadian Donation and Transplantation Research Program, the Canadian Society of Transplantation, and the Sir Peter Morris Centre for Evidence in Transplantation have compiled a list of ongoing clinical trials related to COVID-19 and organ donation, transplantation, immunosuppression, and others.<\/p>\n

A team of information specialists, Robin Featherstone, Liset Pengel, and\u00a0 Marc-Andre Simard, designed and executed a comprehensive search between June 18-21, 2020 with text words and controlled vocabulary terms combining concepts for COVID-19\/SARS-CoV-2 and organ transplantation. Search results were limited to references published since 2019. No language or publication type limits were applied to the search.<\/p>\n

The following clinical trials were identified during this search.\u00a0 This list will be regularly updated.<\/p>\n

Last updated: July 17, 2020<\/p>\n

Download the search strategy here.<\/a><\/p>\n<\/div>

<\/div><\/div><\/div><\/div><\/div>

<\/i><\/i><\/span>Ongoing Clinical Trials - Direct (ODT)<\/span><\/a><\/h4><\/div>
\n

Updated: January 26, 2021
\n<\/span><\/p>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Trial<\/th>Investigator\/Institute<\/th>URL<\/th>\n<\/tr>\n<\/thead>\n
SARS-CoV2 Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)<\/td>Antonio, Secchi<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04487197<\/td>\n<\/tr>\n
COVID-19 in Immunosuppressed Children<\/td>D'Or Institute for, Research
\nEducation,<\/td>		https:\/\/clinicaltrials.gov\/show\/NCT04511429<\/td>\n<\/tr>\n
The efficacy and safety of mesenchymal stem cell transplantation in patients with COVID-19 pneumonia<\/td>Hamedan University of Medical, Sciences<\/td>http:\/\/en.irct.ir\/trial\/49385<\/td>\n<\/tr>\n
SARS-COV-2 Infection in Kidney Transplant Recipients: a Brazilian Multicenter Study<\/td>Helio Tedesco Silva, Junior<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04494776<\/td>\n<\/tr>\n
Effect of COvid-19 on Mental Health in Syrian and Turkish Maintenance HemoDialysis Patients: COST-HD Study<\/td>Sisli Hamidiye Etfal, Training
\nResearch, Hospital<\/td>		https:\/\/clinicaltrials.gov\/show\/NCT04444557<\/td>\n<\/tr>\n
Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 Infection<\/td>University of California, San Diego<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04491227<\/td>\n<\/tr>\n
Corona Virus Infection Among Liver Transplant Recipients<\/td>Dr. Nahed A. Makhlouf, Assiut University<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04565782<\/td>\n<\/tr>\n
Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience From the Middle East<\/td>Hamid Al-Essa Organ Transplant Center<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04542954<\/td>\n<\/tr>\n
Multicenter CTS Pre-and Post-Transplantation Covid-19 Serum Studies<\/td>Heidelberg University<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04694573<\/td>\n<\/tr>\n
Anti-Viral Effects of Voclosporin in COVID-19 Positive Kidney Transplant Recipients<\/td>Leiden University Medical Center<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04701528<\/td>\n<\/tr>\n
Evaluation of short term outcomes of liver transplantation from COVID-19 positive deceased donors<\/td>Mashhad University of Medical Sciences<\/td>http:\/\/www.who.int\/trialsearch\/Trial2.aspx?TrialID=IRCT20200928048867N1<\/td>\n<\/tr>\n
Clinical and immunological predictors of SARS-CoV-2 infection and Covid-19 diseases in patients with renal diseases and healthy persons<\/td>Nierenzentrum Heidelberg e.V., Heidelberg Germany<\/td>http:\/\/www.drks.de\/DRKS00021297<\/td>\n<\/tr>\n
Prevalence and Outcome of SARS-CoV-2 Infection & COVID-19 in Transplant Recipients: The COVITRA Study<\/td>Universitaire Ziekenhuizen, Leuven<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04579471<\/td>\n<\/tr>\n
Maintenance Versus Reduction of Immunosuppression for Renal Transplant Patients Hospitalized With COVID-19 Disease<\/td>Brigham, Women's Hospital<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04420364<\/td>\n<\/tr>\n
Preventative treatment for patients at risk of COVID-19 infection (PROTECT)<\/td>Cambridge University Hospitals, N. H. S. Foundation Trust<\/td>http:\/\/www.isrctn.com\/ISRCTN88057279<\/td>\n<\/tr>\n
AlloSure Guided Immuno-Optimization for COVID-19: An Early Experience<\/td>CareDx<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04341103<\/td>\n<\/tr>\n
Blood Biomarkers as Predictors of COVID-19 Disease Progression in Recently Infected Kidney Transplant Patients<\/td>Centre Hospitalier Universitaire de Nice<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04369456<\/td>\n<\/tr>\n
COVID-19 OUTBREAK AND SOLID ORGAN TRANSPLANTATION (SOT) : AN INTERNATIONAL WEB-BASED SURVEY<\/td>Fondazione Policlinico, Universitario Agostino Gemelli IRCCS<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04367896<\/td>\n<\/tr>\n
Multicentric Study of Coronavirus Disease 2019 (COVID-2019) in Solid Organ Transplant Recipients<\/td>Fundacion Publica Andaluza para la gestion de la Investigacion en Sevilla<\/td>https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04319172<\/td>\n<\/tr>\n
COVID-19 in Liver Transplant Recipients<\/td>Hospital Clinic of Barcelona<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04361591<\/td>\n<\/tr>\n
Coronavirus Outcomes Registries in Immunocompromised Individuals Australia (CORIA)<\/td>Kirby Institute<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04354818<\/td>\n<\/tr>\n
Humoral Immunity Against SARS-CoV-2 in Liver Transplanted Patients in Comparison With Immunocompetent Patients<\/td>Magdalena Salcedo<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04410471<\/td>\n<\/tr>\n
Impact of the Covid-19 Pandemic on Gastrointestinal and Liver Diseases<\/td>Medical University of Graz<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04420637<\/td>\n<\/tr>\n
COVID-19 Pandemic and Worldwide Organ Procurement<\/td>Paris Translational Research Center for Organ Transplantation<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04416256<\/td>\n<\/tr>\n
Observational Study Concerning COVID-19 Infection in Transplanted Kidney, Pancreas or Pancreatic Islet Patients<\/td>IRCCS San Raffaele<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04377776<\/td>\n<\/tr>\n
Assessment of the Impact of COVID-19 on Transplant Patients and on Patients Awaiting Transplantation<\/td>University Hospital, Bordeaux<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04376775<\/td>\n<\/tr>\n
Solid Organ Transplant Recipients With Covid-19 French Registry<\/td>University Hospital, Strasbourg France<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04360707<\/td>\n<\/tr>\n
COVID-19 Research in Organ Transplant Recipients<\/td>Vastra Gotaland Region<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04407221<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n<\/div><\/div><\/div><\/div><\/div>

<\/i><\/i><\/span>Ongoing Clinical Trials - Indirect<\/span><\/a><\/h4><\/div>
\n

Updated: January 26, 2021
\n<\/span><\/p>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Title<\/th>Investigator\/Institute<\/th>URL<\/th>\n<\/tr>\n<\/thead>\n
Convalescent Plasma Treatment in COVID-19<\/td>Aga Khan, University<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04476888<\/td>\n<\/tr>\n
Is COVID-19 Transmitted Through Human Milk? Implications for Breastfeeding and Human Milk Banking-Study 1b<\/td>Deborah, O'Connor<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04453982<\/td>\n<\/tr>\n
Therapeutic Plasma Exchange for COVID-19-associated Hyperviscosity<\/td>Emory, University<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04441996<\/td>\n<\/tr>\n
A Phase II, Open Label, Randomized Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications in Moderate Disease<\/td>Indian Council of Medical, Research<\/td>http:\/\/ctri.nic.in\/Clinicaltrials\/pmaindet2.php?trialid=43149<\/td>\n<\/tr>\n
Efficacy of Convalescent Plasma Therapy in Severely Sick COVID-19 Patients: a Pilot Randomized Controlled Trial<\/td>Institute of, Liver
\nBiliary, Sciences<\/td>		http:\/\/ctri.nic.in\/Clinicaltrials\/pmaindet2.php?trialid=43039<\/td>\n<\/tr>\n
Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome (ARDS)<\/td>Lund University, Hospital<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04503057<\/td>\n<\/tr>\n
Stem cell therapy in Covid-19<\/td>Mashhad University of Medical, Sciences<\/td>http:\/\/en.irct.ir\/trial\/48187<\/td>\n<\/tr>\n
Effect of Allicin derivatives capsule in treatment of patients with new Coronavirus<\/td>Mashhad University of Medical, Sciences<\/td>http:\/\/en.irct.ir\/trial\/48869<\/td>\n<\/tr>\n
A Phase II, Open Label, Randomized Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications<\/td>Max Super Speciality Hospital, A. Unit of Devki Devi Foundation<\/td>http:\/\/ctri.nic.in\/Clinicaltrials\/pmaindet2.php?trialid=43332<\/td>\n<\/tr>\n
COVID-19 Convalescent Plasma Treatment in SARS-CoV-2 Infected Patients: Multicenter Interventional Study<\/td>Ministry of Health, Kuwait<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04474340<\/td>\n<\/tr>\n
Study to Evaluate the Safety and Efficacy of XAV-19 in Patients With COVID-19 Induced Moderate Pneumonia<\/td>Nantes University, Hospital<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04453384<\/td>\n<\/tr>\n
RAPA-501-Allo Off-the-Shelf Therapy of COVID-19<\/td>Rapa Therapeutics, L. L. C.<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04482699<\/td>\n<\/tr>\n
Study of investigational medicinal product CYT107 in patients with COVID-19 infection who have a low level of white blood cells in their blood (ILIAD 7 trial)<\/td>Revimmune,<\/td>http:\/\/isrctn.com\/ISRCTN15913068<\/td>\n<\/tr>\n
A Digital Companion for Loneliness During the COVID-19 Pandemic: a Feasibility Study<\/td>The University of, Auckland<\/td>https:\/\/anzctr.org.au\/ACTRN12620000786998.aspx<\/td>\n<\/tr>\n
CovidCare 1 - Surveillance and care for confirmed and suspected patients with COVID-19 in general practice: an observational study<\/td>Universitatsklinikum, Heidelberg<\/td>http:\/\/www.drks.de\/DRKS00022054<\/td>\n<\/tr>\n
Convalescent plasma transfusion therapy in severe COVID-19 patients- a safety, efficacy and dose response study: a structured summary of a study protocol of a phase II randomized controlled trial<\/td>Chowdhury Fr, Hoque A. Chowdhury F. U. H. Amin M. R. Rahim A. Rahman M. M. Yasmin R. Amin M. R. Miah M. T. Kalam M. A. Rahman M. S.<\/td>https:\/\/pubmed.ncbi.nlm.nih.gov\/33106167https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7586693\/pdf\/13063_2020_Article_4734.pdf<\/td>\n<\/tr>\n
TOGETHER 3 Trial: An Adaptive Randomized Platform Trial to Investigate the Efficacy of Novel Agents for Treatment of SARS-CoV-2 Infection Among High-Risk Outpatient Adults. COVID-19<\/td>Mark Cotton, Caroline Neal, Eric Decloedt<\/td>https:\/\/pactr.samrc.ac.za\/TrialDisplay.aspx?TrialID=12194<\/td>\n<\/tr>\n
A Clinical Trial to Assess the Safety and Efficacy of Convalescent Plasma in Severe Covid-19 patients<\/td>Dr Latha B<\/td>http:\/\/www.ctri.nic.in\/Clinicaltrials\/pmaindet2.php?trialid=43005<\/td>\n<\/tr>\n
Clinical trial to evaluate superiority of anti-SARS-CoV-2 convalescent plasma versus standard-of-care in hospitalized patients with mild COVID-19<\/td>Hannover Medical, School<\/td>http:\/\/www.who.int\/trialsearch\/Trial2.aspx?TrialID=EUCTR2020-001936-86-DE<\/td>\n<\/tr>\n
Use of Convalescent Plasma in the treatment of COVID-19<\/td>Hilton Pharma Pvt, Ltd<\/td>http:\/\/en.irct.ir\/trial\/47163<\/td>\n<\/tr>\n
Convalescent Plasma for Severe COVID-19 Patients<\/td>Hospital de Clinicas de Porto, Alegre<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04547660<\/td>\n<\/tr>\n
Efficacy of Convalescent Plasma Therapy in Patients With COVID-19: a Randomized Control Trial<\/td>Institute of, Liver
\nBiliary, Sciences<\/td>		http:\/\/ctri.nic.in\/Clinicaltrials\/pmaindet2.php?trialid=44478<\/td>\n<\/tr>\n
Evaluation of safety and efficacy of convalescent plasma in COVID-19 patients<\/td>International Stemcell Services, Ltd<\/td>http:\/\/www.ctri.nic.in\/Clinicaltrials\/pmaindet2.php?trialid=42849<\/td>\n<\/tr>\n
A clinical trial comparing use of convalescent plasma therapy plus standard treatment to standard treatment alone in patients with severe COVID-19 infection<\/td>Kenyatta University Teaching, Referral and Research Hospital<\/td>https:\/\/pactr.samrc.ac.za\/TrialDisplay.aspx?TrialID=11047<\/td>\n<\/tr>\n
Study of Coagulation Profile and Role of Heparin Like Effect in Patients With COVID-19<\/td>Postgraduate Institute of Medical Education and Research<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04668404<\/td>\n<\/tr>\n
The Effect of Convalescent Plasma Therapy on Patients with 19-COVID<\/td>Ardabil University of Medical Sciences<\/td>https:\/\/en.irct.ir\/trial\/47594<\/td>\n<\/tr>\n
Adding Colchicine to the Antiretroviral Medication - Lopinavir\/Ritonavir (Kaletra) in Hospitalized Patients with Non-Severe Covid-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomized Controlled Trial<\/td>Biofarma<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04407208<\/td>\n<\/tr>\n
Adding Colchicine to the Antiretroviral Medication - Lopinavir\/Ritonavir (Kaletra) in Hospitalized Patients with Non-Severe Covid-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomized Controlled Trial<\/td>Dalili, N., Kashefizadeh, A., Nafar, M., Poorrezagholi, F., Firouzan, A., Samadian, F., Samavat, S., Ziaie, S., Fatemizadeh, S<\/td>https:\/\/ovidsp.ovid.com\/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=32503620<\/td>\n<\/tr>\n
Evaluating the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in severely ill adults with COVID-19: a structured summary of a study protocol for a randomized controlled trial<\/td>Christina M Eckhardt,\u00a0Matthew J Cummings,\u00a0Kartik N Rajagopalan,\u00a0Sarah Borden,\u00a0Zachary C Bitan,\u00a0Allison Wolf,\u00a0Alex Kantor,\u00a0Thomas Briese,\u00a0Benjamin J Meyer,\u00a0Samuel D Jacobson,\u00a0Dawn Scotto,\u00a0Nischay Mishra,\u00a0Neena M Philip,\u00a0Brie A Stotler,\u00a0Joseph Schwartz,\u00a0Beth Shaz,\u00a0Steven L Spitalnik,\u00a0Andrew Eisenberger,\u00a0Eldad A Hod,\u00a0Jessica Justman,\u00a0Ken Cheung,\u00a0W Ian Lipkin,\u00a0Max R O'Donnell<\/td>https:\/\/pubmed.ncbi.nlm.nih.gov\/32513308<\/td>\n<\/tr>\n
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): a structured summary of a study protocol for a randomised, controlled trial<\/td>Gorman, E., Shankar-Hari, M., Hopkins, P., Tunnicliffe, W. S., Perkins, G. D., Silversides, J., McGuigan, P., Jackson, C., Boyle, R., McFerran, J., McDowell, C., Campbell, C., McFarland, M., Smythe, J., Thompson, J., Williams, B., Curley, G., Laffey, J. G., Clarke, M., O'Kane, C., McAuley, D. F.<\/td>https:\/\/pubmed.ncbi.nlm.nih.gov\/32493473<\/td>\n<\/tr>\n
Convalescent Plasma of Covid-19 to Treat SARS-COV-2 a Randomized Doble Blind 2 Center Trial<\/td>Grupo Mexicano para el Estudio de la Medicina Intensiva<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04405310<\/td>\n<\/tr>\n
Blood Donor Recruitment During Epidemic of COVID-19<\/td>Guangzhou Blood Center<\/td>https:\/\/ClinicalTrials.gov\/show\/NCT04306055<\/td>\n<\/tr>\n
Clinical Use of Stem Cells for the Treatment of Covid-19<\/td>S. B. U. Dr Sadi Konuk Egitim ve Arast\u0131rma Hastanesi<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04392778<\/td>\n<\/tr>\n
Surgical Activity During the Covid-19 Pandemic: Results for 112 Patients in a French Tertiary Care Center<\/td>Hospices Civils de Lyon<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04379232<\/td>\n<\/tr>\n
Mesenchymal Stem Cell for Acute Respiratory Distress Syndrome Due for COVID-19<\/td>Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04416139<\/td>\n<\/tr>\n
Umbilical cord blood therapy to prevent progression of COVID-19 related pneumonia: a structured summary of a study protocol for a pilot randomised controlled trial<\/td>Malhotra, Atul, Ernest, David, Rogers, Benjamin A., Haylock, David, Watt, Ashalyn, Moeneclaey, Guy, Jenkin, Graham<\/td>https:\/\/dx.doi.org\/10.1186\/s13063-020-04387-y<\/td>\n<\/tr>\n
Study to Determine the Immunization Status Among Nephrological Health Care Personnel Against SARS-CoV-2 in a Single Center Over the Course of 12 Months<\/td>Medical University of, Vienna<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04347694<\/td>\n<\/tr>\n
Clinical Study for Human Menstrual Blood-Derived Stem Cells in the Treatment of Acute Novel Coronavirus Pneumonia (COVID-19)<\/td>The First Affiliated Hospital, College of Medicine, Zhejiang University<\/td>http:\/\/www.chictr.org.cn\/showproj.aspx?proj=49146<\/td>\n<\/tr>\n
A Study to Collect Bone Marrow for Process Development and Production of BM-MSC to Treat Severe COVID19 Pneumonitis<\/td>CCTU-Cancer Theme<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04397471<\/td>\n<\/tr>\n
Safety of TY027, a Treatment for COVID-19, in Humans<\/td>Tychan Pte, Ltd<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04429529<\/td>\n<\/tr>\n
Monocytes and NK Cells Activity in Covid-19 Patients<\/td>Universita degli Studi dell'Insubria<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04375176<\/td>\n<\/tr>\n
Role of Ibuprofen and Other Medicines on Severity of Coronavirus Disease 2019<\/td>University Hospital, Bordeaux<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04383899<\/td>\n<\/tr>\n
Safety and Efficacy of Ruxolitinib for COVID-19<\/td>University of Colorado, Denver<\/td>https:\/\/clinicaltrials.gov\/show\/NCT04348071<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n<\/div><\/div><\/div><\/div><\/div>
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