{"id":15651,"date":"2022-05-02T12:38:18","date_gmt":"2022-05-02T17:38:18","guid":{"rendered":"https:\/\/cdtrp.ca\/?page_id=15651"},"modified":"2022-05-10T15:04:06","modified_gmt":"2022-05-10T20:04:06","slug":"prevent-covid","status":"publish","type":"page","link":"https:\/\/cdtrp.ca\/en\/prevent-covid\/","title":{"rendered":"PRospective Evaluation of COVID-19 Vaccine in Transplant Recipients (PREVenT-COVID): A National Strategy"},"content":{"rendered":"

Study Description<\/strong><\/h5>\n

Organ transplant recipients have an increased risk to severe COVID-19 infections and complications. The goal of the PREVenT-COVID study is to examine the immunogenicity and safety of COVID-19 vaccines in both solid organ and hematopoietic stem cell transplants. This ongoing national study involves nine transplant centres connected across four \u00a0provinces.<\/p>\n

This project is funded by the Public Health Agency of Canada<\/strong> (PHAC), through the Vaccine Surveillance Reference group<\/strong> and the COVID-19 Immunity Task Force<\/strong> (CITF). Our lead investigator, Dr. Deepali Kumar, is a transplant infectious diseases physician at the Ajmera Transplant Center apart of the University Health Network (UHN) in Toronto. This study is also co-led by numerous investigators from Ontario, Qu\u00e9bec, British Columbia, and Alberta. With the collaborative efforts of CDTRP, this study brings together both adult and pediatric solid organ and hematopoietic stem cell transplant recipients from across the nation.<\/p>\n<\/div>

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Overall goals of the study<\/strong><\/h5>\n<\/div>
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    Assess the immunogenicity and safety of the COVID-19 vaccines, by evaluating IgG antibody response levels against the receptor binding domain (anti-RBD) of the COVID-19 spike protein. Further immunological responses such as neutralizing antibodies and CD4+ and CD8+ T cell mediated immunity are also being evaluated.<\/p>\n<\/div><\/li>

  • <\/i><\/span>
    \n

    Develop a national safety surveillance system of COVID-19 vaccination amongst transplant recipients.<\/p>\n<\/div><\/li>

  • <\/i><\/span>
    \n

    Coordinate the efforts of national and provincial organizations involved in public health and vaccination research to share current and emerging data.<\/p>\n<\/div><\/li>

  • <\/i><\/span>
    \n

    Build a lasting knowledge transfer platform to rapidly disseminate the research results to patient partners and to public health agencies.<\/p>\n<\/div><\/li><\/ul>

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    Starting in April 2021, patients with either kidney, liver, lung, heart, pancreas, islet cell, and\/or stem cell transplants had been enrolled into the PREVenT-COVID study across the nine collaborating transplant centres in Canada<\/strong>.<\/p>\n

    To assess immunogenicity, blood samples were collected at several time-points, aiming to capture the tolerance of COVID-19 by measuring the production of anti-SARS-CoV-2 antibodies (anti-RBD) within the blood. It takes approximately two weeks for an antibody response to become systemic, thus, to measure anti-RBD antibodies after vaccination, blood collection occurred pre-1st<\/sup> dose, and 3-6 weeks post each vaccine hereafter. This timeline provides both short-term and long-term antibody responses after vaccination, as the final blood collections will coincide with the 6- and 12-month timeline after initial vaccination. Following this scheduling, blood collection from healthy, non-transplant recipient controls will be collected as well to allow for a relative comparison to our transplant cohort. From these blood samples, both serum and peripheral blood mononuclear cells (PBMC) will be isolated for more granular studies.<\/p>\n

    Previous studies have shown that transplant recipients produce insufficient antibody responses against COVID-19, regardless of vaccination. To assess the reasons behind this, variables such as age, sex, time since transplant, vaccine intervals, immunosuppressant regimes, chronic kidney disease and other co-morbidities, will be analyzed and correlated to antibody response.<\/p>\n<\/div>

    <\/div><\/div><\/div><\/div><\/div>
    With approximately 550 transplant recipients enrolled<\/strong>, including both solid organ and hematopoietic stem cell recipients, in adults and pediatrics; PREVenT-COVID is extremely unique and will provide a breadth of new knowledge to the ODT community.<\/em><\/span><\/h5>\n<\/div><\/div><\/div><\/div><\/div>
    Knowledge Translation (KT) Strategy<\/strong><\/h5>\n

    Results of this study will be shared publicly when possible, through its Knowledge Translation whose goals are to:<\/p>\n

      \n
    1. Promote evidence informed policy action for COVID-19 vaccine for transplant patients;<\/li>\n
    2. Engage and inform transplant patients & their families about their safety and immune system response to the COVID-19 vaccines.<\/li>\n<\/ol>\n

      This will be done by various channels of communication through CDTRP\u2019s patient, family and donor partners, social media, mass media, scientific publications, written documents, conferences, and local seminar series.<\/p>\n<\/div>

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      List of Collaborators and their Affiliated Sites<\/strong><\/h5>\n

      (in alphabetical order | Updated: April 27, 2022)<\/p>\n<\/div>

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      Canadian Donation and Transplantation Research Program (CDTRP)<\/strong><\/p>\n

        \n
      • Lori West – Principal Investigator<\/li>\n
      • Patricia Gongal \u2013 Executive Director<\/li>\n
      • Demitra Yotis \u2013 Clinical Data Coordinator<\/li>\n
      • Kristian Stephens \u2013 Knowledge Translation Coordinator<\/li>\n<\/ul>\n

        Centre Hospitalier de l’Universit\u00e9 de Montr\u00e9al (CHUM)<\/strong><\/p>\n

          \n
        • Marie-Jos\u00e9e H\u00e9bert – Principal Investigator<\/li>\n
        • H\u00e9lo\u00efse Cardinal \u2013\u00a0Principal Investigator<\/li>\n
        • Zineb Khrifi \u2013 Clinical Coordinator<\/li>\n
        • Julie Turgeon \u2013 Clinical Coordinator<\/li>\n<\/ul>\n

          Dalhousie University<\/strong><\/p>\n

            \n
          • Karina Top – Principal Investigator<\/li>\n<\/ul>\n

            H\u00e9ma-Qu\u00e9bec<\/strong><\/p>\n

              \n
            • M\u00e9lanie Dieud\u00e9 – Principal Investigator<\/li>\n
            • Marc Cloutier – Scientist<\/li>\n
            • Ren\u00e9e Bazin – Scientist<\/li>\n
            • \u00c9ric Ducas\u00a0\u2013 Research Professional<\/li>\n
            • Sahra Fonseca \u2013 Research Professional<\/li>\n
            • Marie-Jos\u00e9e Fournier \u2013 Research Professional<\/li>\n
            • Patricia Landry \u2013 Research Professional<\/li>\n
            • Nathalie Dussault \u2013 Research Professional<\/li>\n
            • Audrey Laforce-Lavoie \u2013 Research Professional<\/li>\n<\/ul>\n

              H\u00f4pital Maisonneuve-Rosemont (HMR)<\/strong><\/p>\n

                \n
              • Jean-S\u00e9bastien Delisle \u2013 Principal Investigator<\/li>\n
              • C\u00e9dric Carli \u2013 Sample Processing<\/li>\n
              • Gabrielle Boudreau \u2013 Sample Processing<\/li>\n
              • C\u00e9line Nkou\u00e9 \u2013 Research Coordinator<\/li>\n
              • Imran Ahmad \u2013 Local co-investigators<\/li>\n
              • Olivier Veilleux \u2013 Local co-investigators<\/li>\n
              • Jean Roy \u2013 Local co-investigators<\/li>\n<\/ul>\n<\/div>
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                The Hospital for Sick Children (SickKids)<\/strong><\/p>\n

                  \n
                • Shaun Morris \u2013 Principal Investigator<\/li>\n
                • Upton Allen \u2013 Principal Investigator<\/li>\n
                • Chia Wei Teoh \u2013 Principal Investigator<\/li>\n
                • Joerg Krueger \u2013 BMT recruitment<\/li>\n<\/ul>\n

                  Institut de cardiologie de Montr\u00e9al (ICM)<\/strong><\/p>\n

                    \n
                  • Normand Racine \u2013 Principal Investigator<\/li>\n
                  • Maryse Desjardins \u2013 Clinical Coordinator<\/li>\n
                  • H\u00e9l\u00e8ne Brown \u2013 Clinical Coordinator<\/li>\n
                  • Johanne Doiron \u2013 Administrative Agent<\/li>\n<\/ul>\n

                    Institut national de sant\u00e9 publique du Qu\u00e9bec (INSPQ)<\/strong><\/p>\n

                      \n
                    • Gaston DeSerres \u2013 Principal Investigator<\/li>\n<\/ul>\n

                      London Health Sciences Centre (LHSC)<\/strong><\/p>\n

                        \n
                      • Cadence Baker \u2013 Research Manager<\/li>\n
                      • Sarah Shalhoub \u2013 Principal Investigator<\/li>\n
                      • Grant Luke \u2013 Research Assistant<\/li>\n<\/ul>\n

                        Universit\u00e9 Laval<\/strong><\/p>\n

                          \n
                        • Christopher Lemieux \u2013 Principal Investigator<\/li>\n
                        • Sacha De Serres \u2013 Principal Investigator<\/li>\n
                        • France Samson \u2013 Clinical Coordinator<\/li>\n
                        • Margarita Becerra Perez \u2013 Research Coordinator<\/li>\n
                        • Melanie Bradley \u2013 Research Coordinator<\/li>\n<\/ul>\n

                          University Health Network (UHN)<\/strong><\/p>\n

                            \n
                          • Deepali Kumar \u2013 Lead Investigator<\/li>\n
                          • Atul Humar – Principal Investigator<\/li>\n
                          • Victor Ferreira – Principal Investigator<\/li>\n
                          • Sasan Hosseini-Moghaddam \u2013 Principal Investigator<\/li>\n
                          • Natalia Pinzon \u2013 Clinical Coordinator<\/li>\n
                          • Matthew Ierullo \u2013 Research Technician<\/li>\n<\/ul>\n<\/div>
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                            University of Alberta (UofA)<\/strong><\/p>\n

                              \n
                            • Dima Kabbani – Principal Investigator<\/li>\n
                            • Kimberly Robertson \u2013 Clinical Coordinator<\/li>\n
                            • Heather Mangan \u2013 Clinical Coordinator<\/li>\n
                            • Varalika Tyagi \u2013 Undergraduate Student<\/li>\n<\/ul>\n

                              University of Alberta (UofA) | Pediatrics<\/strong><\/p>\n

                                \n
                              • Catherine Burton \u2013 Principal Investigator<\/li>\n
                              • Sneha Suresh \u2013 Principal Investigator<\/li>\n
                              • Joan Robinson \u2013 Principal Investigator<\/li>\n
                              • Cheri Robert \u2013 Clinical Coordinator<\/li>\n<\/ul>\n

                                University of British Columbia (UBC)<\/strong><\/p>\n

                                  \n
                                • Sara Belga \u2013\u00a0Principal Investigator<\/li>\n
                                • Megan Levings \u2013 Principal Investigator<\/li>\n
                                • Gale Ladua \u2013 Clinical Coordinator<\/li>\n<\/ul>\n

                                  University of British Columbia (UBC) | Pediatrics<\/strong><\/p>\n

                                    \n
                                  • Hana Mitchell \u2013 Principal Investigator<\/li>\n
                                  • Candice Weidman \u2013 Clinical Coordinator<\/li>\n
                                  • Tom Blydt-Hansen \u2013 Principal Investigator<\/li>\n
                                  • Manish Sadarangani \u2013 Principal Investigator<\/li>\n
                                  • Amanda Li \u2013 BMT recruitment<\/li>\n
                                  • Monica Ho \u2013 Clinical Coordinator<\/li>\n<\/ul>\n

                                    Vancouver Coastal Health Research Institute (VCH)<\/strong><\/p>\n

                                      \n
                                    • Allison Mah \u2013 Principal Investigator<\/li>\n<\/ul>\n<\/div>
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